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dc.contributor.authorBethlehem, R. A. I.en
dc.contributor.authorLombardo, Michael V.en
dc.contributor.authorLai, Meng-Chuanen
dc.contributor.authorAuyeung, Bonnieen
dc.contributor.authorCrockford, S. K.en
dc.contributor.authorDeakin, J. B.en
dc.contributor.authorSoubramanian, S.en
dc.contributor.authorSule, A.en
dc.contributor.authorKundu, Prantiken
dc.contributor.authorVoon, Valerieen
dc.contributor.authorBaron-Cohen, Simonen
dc.creatorBethlehem, R. A. I.en
dc.creatorLombardo, Michael V.en
dc.creatorLai, Meng-Chuanen
dc.creatorAuyeung, Bonnieen
dc.creatorCrockford, S. K.en
dc.creatorDeakin, J. B.en
dc.creatorSoubramanian, S.en
dc.creatorSule, A.en
dc.creatorKundu, Prantiken
dc.creatorVoon, Valerieen
dc.creatorBaron-Cohen, Simonen
dc.description.abstractOxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. Here, we investigate the impact of oxytocin on resting-state connectivity between subcortical and cortical networks in women. We collected resting-state functional magnetic resonance imaging (fMRI) data on 26 typically developing women 40 min following intranasal oxytocin administration using a double-blind placebo-controlled crossover design. Independent components analysis (ICA) was applied to examine connectivity between networks. An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR. In women, OXTR was highly expressed in striatal and other subcortical regions, but showed modest expression in cortical areas. Oxytocin increased connectivity between corticostriatal circuitry typically involved in reward, emotion, social communication, language and pain processing. This effect was 1.39 standard deviations above the null effect of no difference between oxytocin and placebo. This oxytocin-related effect on corticostriatal connectivity covaried with autistic traits, such that oxytocin-related increase in connectivity was stronger in individuals with higher autistic traits. In sum, oxytocin strengthened corticostriatal connectivity in women, particularly with cortical networks that are involved in social-communicative, motivational and affective processes. This effect may be important for future work on neurological and psychiatric conditions (for example, autism), particularly through highlighting how oxytocin may operate differently for subsets of individuals.en
dc.sourceTranslational Psychiatryen
dc.titleIntranasal oxytocin enhances intrinsic corticostriatal functional connectivity in womenen
dc.description.endingpagee1099Σχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and EducationΤμήμα Ψυχολογίας / Department of Psychology
dc.description.notesPT: Jen
dc.contributor.orcidLombardo, Michael V. [0000-0001-6780-8619]

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