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Trace detection of endogenous human volatile organic compounds for search, rescue and emergency applications
(2015)
Since Pauling's paper in the 1970s, interest has increased in volatile organic compounds (VOCs) released from different bio-fluids, such as blood and urine. A number of VOCs reflect internal biochemical pathways occurring ...
Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity
(2013)
Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...
Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes
(2011)
The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
40LoVe and Samba are involved in Xenopusneural development and functionally distinct from hnRNP AB
(2014)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a large group of modular RNA-binding proteins classified according to their conserved domains. This modular nature, coupled with a large choice of alternative ...
A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes
(2011)
A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...
Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity
(2016)
Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...
The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis
(2014)
Nucleotide-binding proteins Nubp1 and Nubp2 are MRP/MinD-type P-loop NTPases with sequence similarity to bacterial division site-determining proteins and are conserved, essential proteins throughout the Eukaryotes. They ...
Cross-talk among epigenetic modifications: Lessons from histone arginine methylation
(2013)
Epigenetic modifications, including those occurring on DNA and on histone proteins, control gene expression by establishing and maintaining different chromatin states. In recent years, it has become apparent that epigenetic ...