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Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity
(2013)
Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...
Insulin-mimetic action of vanadium compounds on osteoblast-like cells in culture
(1997)
Vanadium compounds mimic insulin actions in different cell types. The present study concerns the insulin-like effects of three vanadium(V) derivatives and one vanadium(IV) complex on osteoblast-like (UMR106 and MC3T3E1) ...
Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes
(2011)
The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
40LoVe and Samba are involved in Xenopusneural development and functionally distinct from hnRNP AB
(2014)
Heterogeneous nuclear ribonucleoproteins (hnRNPs) comprise a large group of modular RNA-binding proteins classified according to their conserved domains. This modular nature, coupled with a large choice of alternative ...
A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes
(2011)
A significant number of environmental microorganisms can cause serious, even fatal, acute and chronic infections in humans. The severity and outcome of each type of infection depends on the expression of specific bacterial ...
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
(2008)
A major obstacle to creating precisely expressed transgenes lies in the epigenetic effects of the host chromatin that surrounds them. Here we present a strategy to overcome this problem, employing a Gal4-inducible luciferase ...
Structure-activity relationships of brassinin in preventing the development of carcinogen-induced mammary lesions in organ culture
(1994)
Brassinin, a pkytoalexin, is found in Chinese cabbage. Previously, we showed that brassinin significantly inhibited dimethylbenz(a)anthracene (DMBA)-induced mammary lesions in organ culture. Moreover, it was an effective ...
Efficacy of garbanzo and soybean flour in suppression of aberrant crypt foci in the colons of CF-1 mice
(2004)
Background: Epidemiological studies have reported a low incidence of colon cancer in countries with high legume consumption. Moreover, experimental studies have found that legumes, such as soybeans and pinto beans, have ...
Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity
(2016)
Changes in histone modifications are an attractive model through which environmental signals, such as diet, could be integrated in the cell for regulating its lifespan. However, evidence linking dietary interventions with ...
The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis
(2014)
Nucleotide-binding proteins Nubp1 and Nubp2 are MRP/MinD-type P-loop NTPases with sequence similarity to bacterial division site-determining proteins and are conserved, essential proteins throughout the Eukaryotes. They ...