Browsing Τμήμα Χημείας / Department of Chemistry by Author "Vilar, R."
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Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes
Georgiades, Savvas N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Firouz Mohd Mustapa, M.; Polychroni, Christoulla; Woscholski, R.; Vilar, R. (2011)The discovery of small-molecule modulators of signaling pathways is currently a particularly active area of research. We aimed at developing unprecedented metal-based activators of Akt signaling which can potentially find ...
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Article
Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes
Child, E. S.; Georgiades, Savvas N.; Rose, K. N.; Stafford, V. S.; Patel, C. B. K.; Steinke, J. H. G.; Mann, D. J.; Vilar, R. (2011)Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify ...
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Interaction of metal complexes with G-quadruplex DNA
Georgiades, Savvas N.; Abd Karim, N. H.; Suntharalingam, K.; Vilar, R. (2010)[Figure Presented] Guanine-rich sequences of DNA can assemble into tetrastranded structures known as G-quadruplexes. It has been suggested that these secondary DNA structures could be involved in the regulation of several ...
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Interaction of metal complexes with nucleic acids
Georgiades, Savvas N.; Vilar, R. (2010)This chapter reviews the literature reported during 2009 in the field of interaction of metal complexes with nucleic acids, also covering complex formation between transition metal ions and coordinating moieties within ...
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A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain
Mak, L. H.; Georgiades, Savvas N.; Rosivatz, E.; Whyte, G. F.; Mirabelli, M.; Vilar, R.; Woscholski, R. (2011)Inositol phospholipids have emerged as important key players in a wide variety of cellular functions. Among the seven existing inositol phospholipids, phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) has attracted much ...