dc.contributor.author | Bonovas, Stefanos | en |
dc.contributor.author | Fiorino, Gionata | en |
dc.contributor.author | Lytras, Theodoros | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Peyrin-Biroulet, L. | en |
dc.contributor.author | Danese, Silvio | en |
dc.creator | Bonovas, Stefanos | en |
dc.creator | Fiorino, Gionata | en |
dc.creator | Lytras, Theodoros | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Peyrin-Biroulet, L. | en |
dc.creator | Danese, Silvio | en |
dc.date.accessioned | 2018-06-22T09:52:34Z | |
dc.date.available | 2018-06-22T09:52:34Z | |
dc.date.issued | 2017 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41420 | |
dc.description.abstract | Background: The relationship of 5-aminosalicylates’ use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. Aim: To investigate this association through an updated meta-analysis of observational studies. Methods: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates were calculated using random-effect models. Detailed subgroup analyses were performed. The GRADE approach was used to assess the quality of evidence. Results: Thirty-one independent observational studies including 2137 cases of colorectal neoplasia (of which 76% were cancers) were incorporated. Between-study heterogeneity was moderate, while strong suspicion of small-study effects was raised. The overall analysis revealed a protective association between 5-aminosalicylates’ use and colorectal neoplasia (RR = 0.57, 95% CI: 0.45–0.71). When the analysis was stratified according to study design and setting, the association was significant in cohort (RR = 0.65, 95% CI: 0.43–0.99; n = 10) and case–control studies (RR = 0.53, 95% CI: 0.40–0.70; n = 21), population-based (RR = 0.70, 95% CI: 0.52–0.94; n = 12) and hospital-based studies (RR = 0.46, 95% CI: 0.34–0.61; n = 19). Exposure to 5-aminosalicylates was protective against cancer (RR = 0.58, 95% CI: 0.45–0.74) and dysplasia (RR = 0.54, 95% CI: 0.35–0.84). The reduction in colorectal neoplasia risk was strong in ulcerative colitis (RR = 0.50, 95% CI: 0.38–0.64), but nonsignificant in Crohn's disease (RR = 0.76, 95% CI: 0.43–1.33). Mesalazine (mesalamine) use was protective (RR = 0.70, 95% CI: 0.51–0.94) with evidence of a dose-effect. The effect of sulfasalazine was marginally nonsignificant (RR = 0.72, 95% CI: 0.51–1.01). Conclusions: Our findings support a potential chemopreventive role of 5-aminosalicylates in IBD. Further, high-quality prospective research is warranted. © 2017 John Wiley & Sons Ltd | en |
dc.language.iso | eng | en |
dc.source | Alimentary Pharmacology and Therapeutics | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Meta analysis | en |
dc.subject | Colorectal neoplasms | en |
dc.subject | Anti-inflammatory agents | en |
dc.subject | Colitis | en |
dc.subject | Crohn disease | en |
dc.subject | Mesalamine | en |
dc.subject | Mesalazine | en |
dc.subject | Non-steroidal | en |
dc.subject | Nonsteroid antiinflammatory agent | en |
dc.subject | Risk | en |
dc.subject | Ulcerative | en |
dc.title | Systematic review with meta-analysis: use of 5-aminosalicylates and risk of colorectal neoplasia in patients with inflammatory bowel disease | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/apt.14023 | |
dc.description.volume | 45 | |
dc.description.issue | 9 | |
dc.description.startingpage | 1179 | |
dc.description.endingpage | 1192 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bonovas, Stefanos [0000-0001-6102-6579] | |
dc.contributor.orcid | Fiorino, Gionata [0000-0001-5623-2968] | |
dc.contributor.orcid | Danese, Silvio [0000-0001-7341-1351] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0001-6102-6579 | |
dc.gnosis.orcid | 0000-0001-5623-2968 | |
dc.gnosis.orcid | 0000-0001-7341-1351 | |