Systematic review with meta-analysis: use of 5-aminosalicylates and risk of colorectal neoplasia in patients with inflammatory bowel disease
Nikolopoulos, Georgios K.
SourceAlimentary Pharmacology and Therapeutics
Google Scholar check
MetadataShow full item record
Background: The relationship of 5-aminosalicylates’ use with the risk of colorectal neoplasia in patients with inflammatory bowel disease (IBD) has been the focus of a growing body of research. Aim: To investigate this association through an updated meta-analysis of observational studies. Methods: PubMed, Scopus and major conference proceedings were searched up to December 2016. The identified studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates were calculated using random-effect models. Detailed subgroup analyses were performed. The GRADE approach was used to assess the quality of evidence. Results: Thirty-one independent observational studies including 2137 cases of colorectal neoplasia (of which 76% were cancers) were incorporated. Between-study heterogeneity was moderate, while strong suspicion of small-study effects was raised. The overall analysis revealed a protective association between 5-aminosalicylates’ use and colorectal neoplasia (RR = 0.57, 95% CI: 0.45–0.71). When the analysis was stratified according to study design and setting, the association was significant in cohort (RR = 0.65, 95% CI: 0.43–0.99; n = 10) and case–control studies (RR = 0.53, 95% CI: 0.40–0.70; n = 21), population-based (RR = 0.70, 95% CI: 0.52–0.94; n = 12) and hospital-based studies (RR = 0.46, 95% CI: 0.34–0.61; n = 19). Exposure to 5-aminosalicylates was protective against cancer (RR = 0.58, 95% CI: 0.45–0.74) and dysplasia (RR = 0.54, 95% CI: 0.35–0.84). The reduction in colorectal neoplasia risk was strong in ulcerative colitis (RR = 0.50, 95% CI: 0.38–0.64), but nonsignificant in Crohn's disease (RR = 0.76, 95% CI: 0.43–1.33). Mesalazine (mesalamine) use was protective (RR = 0.70, 95% CI: 0.51–0.94) with evidence of a dose-effect. The effect of sulfasalazine was marginally nonsignificant (RR = 0.72, 95% CI: 0.51–1.01). Conclusions: Our findings support a potential chemopreventive role of 5-aminosalicylates in IBD. Further, high-quality prospective research is warranted. © 2017 John Wiley & Sons Ltd