dc.contributor.author | Protopsaltis, J. | en |
dc.contributor.author | Kokkoris, Stelios | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Spyropoulou, P. | en |
dc.contributor.author | Katsaros, T. | en |
dc.contributor.author | Salvanos, L. | en |
dc.contributor.author | Brestas, Paris | en |
dc.contributor.author | Korantzopoulos, Panagiotis | en |
dc.contributor.author | Melidonis, Andreas | en |
dc.creator | Protopsaltis, J. | en |
dc.creator | Kokkoris, Stelios | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Spyropoulou, P. | en |
dc.creator | Katsaros, T. | en |
dc.creator | Salvanos, L. | en |
dc.creator | Brestas, Paris | en |
dc.creator | Korantzopoulos, Panagiotis | en |
dc.creator | Melidonis, Andreas | en |
dc.date.accessioned | 2018-06-22T09:53:01Z | |
dc.date.available | 2018-06-22T09:53:01Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41615 | |
dc.description.abstract | Objective: The aim of this study was to elucidate if apoptosis dysregulation is present in type 1 diabetic patients with microalbuminuria. Subjects and Methods: The following variables were determined in 29 type 1 diabetic patients: the duration of diabetes, soluble Fas (sFas), Bcl-2, hemoglobin A1c levels, glomerular filtration rate (GFR) and microalbuminuria, using the urine albumin to urine creatinine ratio (ACR). Age and gender were assessed and patients were categorized into two groups, according to their ACR: the microalbuminuric (MA) group with an ACR ≥30 mg/g, and the normoalbuminuric (NA) group with an ACR <30 mg/g. Results: The differences between the two groups regarding sFas, Bcl-2 and GFR were not statistically significant. However, in the MA group, a significant positive relationship between sFas and ACR was observed (r = 0.736, p = 0.015). Dividing patients into two subgroups - mild versus severe (ACR ≥150 mg/g) microalbuminuric patients - significant differences in sFas (60.4 vs. 87.2 pg/ml; p = 0.047) and GFR (113 vs. 69.5 ml min-1 1.73 m-2; p = 0.021) were observed, whereas in Bcl-2, the difference was not significant (77.96 vs. 71.13 ng/ml). Conclusions: At the early stages of diabetic nephropathy in type 1 diabetic patients, there seems to be a dysregulation of apoptosis, as expressed by enhanced sFas levels, leading to the speculation that the prevalence of antiapoptotic mechanisms (sFas) may promote mesangial proliferation. Copyright © 2007 S. Karger AG. | en |
dc.language.iso | eng | en |
dc.source | Medical Principles and Practice | en |
dc.subject | Statistics | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Clinical article | en |
dc.subject | Statistical significance | en |
dc.subject | Diabetes | en |
dc.subject | Male | en |
dc.subject | Age distribution | en |
dc.subject | Correlation analysis | en |
dc.subject | Sex difference | en |
dc.subject | Protein bcl 2 | en |
dc.subject | Disease duration | en |
dc.subject | Disease severity | en |
dc.subject | Protein blood level | en |
dc.subject | Creatinine | en |
dc.subject | Apoptosis | en |
dc.subject | Albumin | en |
dc.subject | Hemoglobins | en |
dc.subject | Fas ligand protein | en |
dc.subject | Nonparametric | en |
dc.subject | Hemoglobin blood level | en |
dc.subject | Diabetes mellitus | en |
dc.subject | Diabetic patient | en |
dc.subject | Albuminuria | en |
dc.subject | Creatinine urine level | en |
dc.subject | Diabetic nephropathy | en |
dc.subject | Enzyme-linked immunosorbent assay | en |
dc.subject | Fas antigen | en |
dc.subject | Glomerulus filtration rate | en |
dc.subject | Hemoglobin a1c | en |
dc.subject | Insulin dependent diabetes mellitus | en |
dc.subject | Microalbuminuria | en |
dc.subject | Soluble fas | en |
dc.subject | Type 1 | en |
dc.subject | Urinary albumin | en |
dc.subject | Urine level | en |
dc.title | Correlation between increased serum sFas levels and microalbuminuria in type 1 diabetic patients | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1159/000100394 | |
dc.description.volume | 16 | |
dc.description.issue | 3 | |
dc.description.startingpage | 222 | |
dc.description.endingpage | 225 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |