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dc.contributor.authorTsantes, Argirio E.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorRapti, E.en
dc.contributor.authorMantzios, Georgios P.en
dc.contributor.authorKapsimali, Violettaen
dc.contributor.authorTravlou, Anthi S.en
dc.creatorTsantes, Argirio E.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBagos, Pantelis G.en
dc.creatorRapti, E.en
dc.creatorMantzios, Georgios P.en
dc.creatorKapsimali, Violettaen
dc.creatorTravlou, Anthi S.en
dc.date.accessioned2018-06-22T09:53:16Z
dc.date.available2018-06-22T09:53:16Z
dc.date.issued2007
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41750
dc.description.abstractThe effect of the 675 insertion/deletion (4G/5G) polymorphism of plasminogen activator inhibitor-1 (PAI-1) gene on the risk of venous thromboembolism (VTE) remains controversial. In this study, we performed a meta-analysis of published data regarding this issue. A comprehensive electronic search was carried out up until September 2006.A total of 22 articles were included in the analysis that was performed using random effects models. Eighteen papers, concerning patients without another known risk factor, comprised 2,644 cases and 3,739 controls. The alleles contrast (4G vs. 5G allele) yielded a statistically significant odds ratio (OR) of 1.153 (95% confidence interval [CI]: 1.068-1.246). In a sub-analysis of five studies that included 256 cases with another genetic risk factor and 147 controls, the combined per-allele OR was still significant (OR: 1.833,95% CI: 1.325-2.536). On the contrary, the analysis of five studies regarding cases with a non-genetic risk factor for VTE (antiphospholipid antibody syndrome, Behcet disease) provided insignificant results in all aspects. There was no evidence for heterogeneity and publication bias in all analyses. Based on our findings, the 4G allele appears to increase the risk of venous thrombosis, particularly in subjects with other genetic thrombophilic defects. Recommendation for detection of this polymorphism in evaluating thrombophilia in such patients might be considered. © 2007 Schattauer GmbH, Stuttgart.en
dc.language.isoengen
dc.sourceThrombosis and haemostasisen
dc.subjectPublishingen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectStatistical significanceen
dc.subjectMedical literatureen
dc.subjectConfidence intervalen
dc.subjectAlleleen
dc.subjectGenetic heterogeneityen
dc.subjectOdds ratioen
dc.subjectPolymorphismen
dc.subjectGeneticen
dc.subjectGenetic polymorphismen
dc.subjectGenetic predisposition to diseaseen
dc.subjectRisk factorsen
dc.subjectRisk assessmenten
dc.subjectRisk factoren
dc.subjectGene deletionen
dc.subjectGene frequencyen
dc.subjectGenetic risken
dc.subjectPlasminogen activator inhibitor 1en
dc.subject4g/5g genetic polymorphismen
dc.subjectAntiphospholipid syndromeen
dc.subjectBehcet diseaseen
dc.subjectGene insertionen
dc.subjectPai-ien
dc.subjectThromboembolismen
dc.subjectThrombophiliaen
dc.subjectVenous thromboembolismen
dc.subjectVenous thrombosisen
dc.titleAssociation between the plasminogen activator inhibitor-1 4G/5G polymorphism and venous thrombosisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1160/TH06-12-0745
dc.description.volume97
dc.description.issue6
dc.description.startingpage907
dc.description.endingpage913
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]


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