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dc.contributor.authorSzucs, Z.en
dc.contributor.authorThway, K.en
dc.contributor.authorFisher, Cyrilen
dc.contributor.authorBulusu, Rameshen
dc.contributor.authorConstantinidou, Anastasiaen
dc.contributor.authorBenson, Charlotteen
dc.contributor.authorGraaf, W. T. A. van deren
dc.contributor.authorJones, Robin Lewisen
dc.creatorSzucs, Z.en
dc.creatorThway, K.en
dc.creatorFisher, Cyrilen
dc.creatorBulusu, Rameshen
dc.creatorConstantinidou, Anastasiaen
dc.creatorBenson, Charlotteen
dc.creatorGraaf, W. T. A. van deren
dc.creatorJones, Robin Lewisen
dc.date.accessioned2018-06-22T09:53:17Z
dc.date.available2018-06-22T09:53:17Z
dc.date.issued2017
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41757
dc.description.abstractPrimary and secondary resistance to currently available licensed tyrosine kinase inhibitors poses a real clinical challenge in the management of advanced gastrointestinal stromal tumors. Within the frame of early phase clinical trials novel systemic treatments are currently being evaluated to target both the well explored and novel emerging downstream effectors of KIT and PDGFRA signaling. Alternative therapeutic approaches also include exploring novel inhibitors of the KIT/PDGFRA receptors, immune checkpoint and cyclin-dependent kinase inhibitors. The final clinical trial outcome data for these agents are highly anticipated. Integration of new diagnostic techniques into routine clinical practice can potentially guide tailored delivery of agents in the treatment of a highly polyclonal, heterogeneous disease such as heavily pretreated advanced gastrointestinal stromal tumor. © 2016 Robin L Jones.en
dc.language.isoengen
dc.sourceFuture Oncologyen
dc.subjectGisten
dc.subjectKiten
dc.subjectNovel therapyen
dc.subjectPfgfraen
dc.titlePromising novel therapeutic approaches in the management of gastrointestinal stromal tumorsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.2217/fon-2016-0194
dc.description.volume13
dc.description.issue2
dc.description.startingpage185
dc.description.endingpage194
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidConstantinidou, Anastasia [0000-0001-5316-7574]
dc.gnosis.orcid0000-0001-5316-7574


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