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dc.contributor.authorStoychkov, J. N.en
dc.contributor.authorSchultz, R. M.en
dc.contributor.authorChirigos, M. A.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorGoldin, A.en
dc.creatorStoychkov, J. N.en
dc.creatorSchultz, R. M.en
dc.creatorChirigos, M. A.en
dc.creatorPavlidis, Nicholasen
dc.creatorGoldin, A.en
dc.date.accessioned2018-06-22T09:53:19Z
dc.date.available2018-06-22T09:53:19Z
dc.date.issued1979
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41777
dc.description.abstractThe effects of i.p. and s.c. Adriamycin and cyclophosphamide treatment of BALB/c x DBA/2F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and Bacillus Calmette-Guérin, on macrophage cytotoxic ability, As assessed by direct viable cell counts of MBL-2 leukemia cells, both Adriamycin and cyclophosphamide produced growth-inhibitory macrophages. This function after s.c. cytostatic treatment peaked at Day 1 and decreased progressively, attaining normal control values by Day 6. When adjuvants, such as pyran and B. Calmette-Guérin, were administered i.p. simultaneously with s.c. Adriamycin or cyclophosphamide, adjuvant-induced cytotoxic function was not markedly affected. A better knowledge of the influence of cytostatic agents alone or combined with immunoadjuvants on macrophage cytotoxic ability may be useful in designing more effective chemoimmunotherapy protocols.en
dc.language.isoengen
dc.sourceCancer researchen
dc.subjectMaleen
dc.subjectTime factorsen
dc.subjectDose-response relationshipen
dc.subjectDrugen
dc.subjectAnimalsen
dc.subjectMiceen
dc.subjectImmunologicen
dc.subjectDoxorubicinen
dc.subjectCyclophosphamideen
dc.subjectCytotoxicityen
dc.subjectMacrophagesen
dc.subjectPyran copolymeren
dc.subjectInbred strainsen
dc.subjectIn vitro techniquesen
dc.subjectBcg vaccineen
dc.titleEffects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in miceen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume39
dc.description.issue8
dc.description.startingpage3014
dc.description.endingpage3017
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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