dc.contributor.author | Stoychkov, J. N. | en |
dc.contributor.author | Schultz, R. M. | en |
dc.contributor.author | Chirigos, M. A. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Goldin, A. | en |
dc.creator | Stoychkov, J. N. | en |
dc.creator | Schultz, R. M. | en |
dc.creator | Chirigos, M. A. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Goldin, A. | en |
dc.date.accessioned | 2018-06-22T09:53:19Z | |
dc.date.available | 2018-06-22T09:53:19Z | |
dc.date.issued | 1979 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41777 | |
dc.description.abstract | The effects of i.p. and s.c. Adriamycin and cyclophosphamide treatment of BALB/c x DBA/2F1 mice were studied alone and in combination with immunotherapeutic agents, pyran copolymer and Bacillus Calmette-Guérin, on macrophage cytotoxic ability, As assessed by direct viable cell counts of MBL-2 leukemia cells, both Adriamycin and cyclophosphamide produced growth-inhibitory macrophages. This function after s.c. cytostatic treatment peaked at Day 1 and decreased progressively, attaining normal control values by Day 6. When adjuvants, such as pyran and B. Calmette-Guérin, were administered i.p. simultaneously with s.c. Adriamycin or cyclophosphamide, adjuvant-induced cytotoxic function was not markedly affected. A better knowledge of the influence of cytostatic agents alone or combined with immunoadjuvants on macrophage cytotoxic ability may be useful in designing more effective chemoimmunotherapy protocols. | en |
dc.language.iso | eng | en |
dc.source | Cancer research | en |
dc.subject | Male | en |
dc.subject | Time factors | en |
dc.subject | Dose-response relationship | en |
dc.subject | Drug | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | Immunologic | en |
dc.subject | Doxorubicin | en |
dc.subject | Cyclophosphamide | en |
dc.subject | Cytotoxicity | en |
dc.subject | Macrophages | en |
dc.subject | Pyran copolymer | en |
dc.subject | Inbred strains | en |
dc.subject | In vitro techniques | en |
dc.subject | Bcg vaccine | en |
dc.title | Effects of adriamycin and cyclophosphamide treatment on induction of macrophage cytotoxic function in mice | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 39 | |
dc.description.issue | 8 | |
dc.description.startingpage | 3014 | |
dc.description.endingpage | 3017 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |