dc.contributor.author | Tsantes, Argirio E. | en |
dc.contributor.author | Kopterides, Petros | en |
dc.contributor.author | Bonovas, Stefanos | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Antonakos, Georgios | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Gialeraki, Argiri | en |
dc.contributor.author | Kapsimali, Violetta | en |
dc.contributor.author | Kyriakou, Elias | en |
dc.contributor.author | Kokoris, Styliani | en |
dc.contributor.author | Dima, Kleanthi | en |
dc.contributor.author | Armaganidis, Apostolos | en |
dc.contributor.author | Tsangaris, I. | en |
dc.creator | Tsantes, Argirio E. | en |
dc.creator | Kopterides, Petros | en |
dc.creator | Bonovas, Stefanos | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Antonakos, Georgios | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Gialeraki, Argiri | en |
dc.creator | Kapsimali, Violetta | en |
dc.creator | Kyriakou, Elias | en |
dc.creator | Kokoris, Styliani | en |
dc.creator | Dima, Kleanthi | en |
dc.creator | Armaganidis, Apostolos | en |
dc.creator | Tsangaris, I. | en |
dc.date.accessioned | 2018-06-22T09:53:20Z | |
dc.date.available | 2018-06-22T09:53:20Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41785 | |
dc.description.abstract | Background. The role of the D allele of the angiotensin-converting enzyme (ACE) gene I/D polymorphism in the clinical outcomes of patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains controversial. Our aim was to assess simultaneously the effect of the ACE I/D polymorphisms as well as the serum and BALF ACE levels on prognosis of patients with ARDS. Methods. Sixty-nine mechanically ventilated patients with ALI/ARDS were recruited. ACE activity levels both in serum and BALF were assessed by chemical methods. Patients were genotyped for ACE I/D polymorphisms. Time-to-event analysis evaluated the variables associated with the 28-day and 90-day mortality. Finally, we performed a meta-analysis of studies examining the association between ACE I/D polymorphisms and mortality of ALI/ARDS patients. Results. In the multivariable model, age, lung compliance, serum lactate and serum ACE levels were significantly associated with both 28- and 90-day mortality. No significant correlation was found between serum and BALF ACE levels (Spearman's rho=0.054; P=0.66). Serum ACE concentrations were significantly higher (P=0.046) in patients with D/D genotype versus the two other groups combined (I/D and I/I genotypes). The meta-analysis of 6 studies (including ours) provided evidence that D allele is significantly associated with increased mortality in ALI/ARDS patients, yielding a per-allele odds ratio of 1.76 (95% CI: 1.19, 2.59). Conclusion. Serum ACE levels appear to be affected by the I/D polymorphism and are correlated with prognosis in patients with ALI/ARDS indicating that further investigation of the clinical significance of the ACE in ARDS might be of value. | en |
dc.language.iso | eng | en |
dc.source | Minerva anestesiologica | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | 80 and over | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Regression analysis | en |
dc.subject | Prognosis | en |
dc.subject | Prospective studies | en |
dc.subject | Outcome assessment | en |
dc.subject | Male | en |
dc.subject | Mortality | en |
dc.subject | Allele | en |
dc.subject | Genotype | en |
dc.subject | Polymorphism | en |
dc.subject | Genetic polymorphism | en |
dc.subject | Risk factors | en |
dc.subject | Disease association | en |
dc.subject | Lactate blood level | en |
dc.subject | Prednisolone | en |
dc.subject | Gene expression | en |
dc.subject | Acute lung injury | en |
dc.subject | Dipeptidyl carboxypeptidase | en |
dc.subject | Peptidyl-dipeptidase a | en |
dc.subject | Enzyme activity | en |
dc.subject | Adult respiratory distress syndrome | en |
dc.subject | Angiotensin-converting enzyme inhibitors | en |
dc.subject | Bronchoalveolar lavage fluid | en |
dc.subject | Correlation coefficient | en |
dc.subject | Genetic | en |
dc.subject | Lung compliance | en |
dc.subject | Respiratory distress syndrome | en |
dc.subject | Respiratory function tests | en |
dc.subject | Ventilated patient | en |
dc.title | Effect of angiotensin converting enzyme gene I/D polymorphism and its expression on clinical outcome in acute respiratory distress syndrome | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 79 | |
dc.description.issue | 8 | |
dc.description.startingpage | 861 | |
dc.description.endingpage | 870 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.contributor.orcid | Bonovas, Stefanos [0000-0001-6102-6579] | |
dc.contributor.orcid | Kopterides, Petros [0000-0002-7682-4482] | |
dc.contributor.orcid | Kokoris, Styliani [0000-0002-1635-7309] | |
dc.contributor.orcid | Dima, Kleanthi [0000-0001-5284-115X] | |
dc.contributor.orcid | Armaganidis, Apostolos [0000-0002-6630-2648] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |
dc.gnosis.orcid | 0000-0001-6102-6579 | |
dc.gnosis.orcid | 0000-0002-7682-4482 | |
dc.gnosis.orcid | 0000-0002-1635-7309 | |
dc.gnosis.orcid | 0000-0001-5284-115X | |
dc.gnosis.orcid | 0000-0002-6630-2648 | |