dc.contributor.author | Tsiara, Chrissa G. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Goujard, Cecile | en |
dc.contributor.author | Katzenstein, Terese L. | en |
dc.contributor.author | Minga, Albert K. | en |
dc.contributor.author | Rouzioux, C. | en |
dc.contributor.author | Hatzakis, A. | en |
dc.creator | Tsiara, Chrissa G. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Goujard, Cecile | en |
dc.creator | Katzenstein, Terese L. | en |
dc.creator | Minga, Albert K. | en |
dc.creator | Rouzioux, C. | en |
dc.creator | Hatzakis, A. | en |
dc.date.accessioned | 2018-06-22T09:53:22Z | |
dc.date.available | 2018-06-22T09:53:22Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41805 | |
dc.description.abstract | Several studies have reported the prognostic strength of HIV-1 DNA with variable results however. The aims of the current study were to estimate more accurately the ability of HIV-1 DNA to predict progression of HIV-1 disease toward acquired immunodeficiency syndrome (AIDS) or death, and to compare the prognostic information obtained by HIV-1 DNA with that derived from plasma HIV-1 RNA. Eligible articles were identified through a comprehensive search of Medline, ISI Web of Science, Scopus, and Google Scholar. The analysis included univariate and bivariate random-effects models. The univariate meta-analysis of six studies involving 1074 participants showed that HIV-1 DNA was a strong predictive marker of AIDS [relative risk (RR): 3.01, 95% confidence interval (CI): 1.88-4.82] and of all-cause mortality (RR: 3.49, 95% CI: 2.06-5.89). The bivariate model using the crude estimates of primary studies indicated that HIV-1 DNA was a significantly better predictor than HIV-1 RNA of either AIDS alone (ratio of RRs=1.47, 95% CI: 1.05-2.07) or of combined (AIDS or death) progression outcomes (ratio of RRs=1.51, 95% CI: 1.11-2.05). HIV-1 DNA is a strong predictor of HIV-1 disease progression. Moreover, there is some evidence that HIV-1 DNA might have better predictive value than plasma HIV-1 RNA. © 2012, Mary Ann Liebert, Inc. | en |
dc.language.iso | eng | en |
dc.source | AIDS Research and Human Retroviruses | en |
dc.subject | Article | en |
dc.subject | Female | en |
dc.subject | Male | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Disease progression | en |
dc.subject | Predictive value of tests | en |
dc.subject | Priority journal | en |
dc.subject | Prognosis | en |
dc.subject | Disease course | en |
dc.subject | Meta analysis | en |
dc.subject | Intermethod comparison | en |
dc.subject | Biological markers | en |
dc.subject | Medline | en |
dc.subject | Death | en |
dc.subject | Rna | en |
dc.subject | Viral | en |
dc.subject | Virus rna | en |
dc.subject | Dna | en |
dc.subject | Acquired immunodeficiency syndrome | en |
dc.subject | Viral load | en |
dc.subject | Comparative effectiveness | en |
dc.subject | Predictive value | en |
dc.subject | Human immunodeficiency virus 1 | en |
dc.subject | Hiv-1 | en |
dc.subject | Acquired immune deficiency syndrome | en |
dc.subject | Virus dna | en |
dc.title | Impact of HIV type 1 DNA levels on spontaneous disease progression: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1089/aid.2011.0032 | |
dc.description.volume | 28 | |
dc.description.issue | 4 | |
dc.description.startingpage | 366 | |
dc.description.endingpage | 373 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |