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dc.contributor.authorTsantes, Argirio E.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorTsirigotis, P.en
dc.contributor.authorZoi, K.en
dc.contributor.authorZomas, A.en
dc.contributor.authorKapsimali, Violettaen
dc.contributor.authorKopterides, Petrosen
dc.contributor.authorChondropoulos, Spyrosen
dc.contributor.authorDervenoulas, Johnen
dc.contributor.authorMantzios, Georgios P.en
dc.creatorTsantes, Argirio E.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorTsirigotis, P.en
dc.creatorZoi, K.en
dc.creatorZomas, A.en
dc.creatorKapsimali, Violettaen
dc.creatorKopterides, Petrosen
dc.creatorChondropoulos, Spyrosen
dc.creatorDervenoulas, Johnen
dc.creatorMantzios, Georgios P.en
dc.date.accessioned2018-06-22T09:53:23Z
dc.date.available2018-06-22T09:53:23Z
dc.date.issued2011
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41809
dc.description.abstractEssential thrombocythemia is characterized by persistent elevation and functional disturbances of platelets. Both the platelet function analyzer-100 (PFA-100) collagen-epinephrine (CEPI) cartridge and aggregometry with epinephrine are considered sensitive and valid methods in detecting abnormal platelet function in essential thrombocythemia. We attempted to confirm that restoration of abnormal platelet function results from platelet count reduction in essential thrombocythemia, by using these two methods. Thirty-nine essential thrombocythemia patients were divided into two groups on the basis of their platelet count. Group A participants (n = 20) exhibited platelet counts greater than 500 × 10 9/l, whereas group B participants (n = 19) had platelet counts below this limit. Hematological parameters, plasma von Willebrand factor (vWF) antigen and activity levels were assessed. Platelet function was analyzed by the PFA-100 and light transmission aggregometry with epinephrine, collagen, and ADP. The point mutation JAK2 V617F was identified and its effect on platelet function tests was also investigated. By using logistic regression analysis, white blood cell count, vWF activity level, and the measurements of aggregation in response to epinephrine were significantly different between the two groups. Epinephrine-induced aggregation retained the statistical significance in the multivariable procedure (P: 0.002). PFA-100 CEPI closure times were lower-but not statistically significant-in group B. Neither the JAK2 V617F positivity nor different cytoreductive treatments had any influence on ex-vivo platelet function tests. Our findings demonstrate normalization of platelet function resulting from platelet count reduction in essential thrombocythemia and reinforce the concept of lowering platelet counts in these patients. © 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins.en
dc.language.isoengen
dc.sourceBlood Coagulation and Fibrinolysisen
dc.subjectGreeceen
dc.subjectArticleen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectMiddle ageden
dc.subjectRegression analysisen
dc.subjectPriority journalen
dc.subjectHydroxyureaen
dc.subjectClinical articleen
dc.subjectInterferon-alphaen
dc.subjectAdrenalinen
dc.subjectProtein blood levelen
dc.subjectGene mutationen
dc.subjectThrombocyte counten
dc.subjectLongitudinal studiesen
dc.subjectCollagenen
dc.subjectAdenosine diphosphateen
dc.subjectAspirinen
dc.subjectBlood clotting parametersen
dc.subjectBlood plateletsen
dc.subjectEpinephrineen
dc.subjectEssentialen
dc.subjectEssential thrombocythemiaen
dc.subjectEx vivo studyen
dc.subjectHematological parametersen
dc.subjectJanus kinase 2en
dc.subjectLeukocyte counten
dc.subjectPlatelet aggregationen
dc.subjectPlatelet counten
dc.subjectPlatelet count reductionen
dc.subjectPlatelet functionen
dc.subjectPlatelet function testsen
dc.subjectPoint mutationen
dc.subjectThrombocyte aggregationen
dc.subjectThrombocyte functionen
dc.subjectThrombocythemiaen
dc.subjectThrombocythemiaen
dc.subjectVon willebrand factoren
dc.titleDirect evidence for normalization of platelet function resulting from platelet count reduction in essential thrombocythemiaen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1097/MBC.0b013e3283488494
dc.description.volume22
dc.description.issue6
dc.description.startingpage457
dc.description.endingpage462
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidDervenoulas, John [0000-0001-8395-507X]
dc.contributor.orcidKopterides, Petros [0000-0002-7682-4482]
dc.contributor.orcidChondropoulos, Spyros [0000-0002-6062-7935]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0001-8395-507X
dc.gnosis.orcid0000-0002-7682-4482
dc.gnosis.orcid0000-0002-6062-7935


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