• Article  

      Chemotherapy cytotoxicity of human MCF-7 and MDA-MB 231 breast cancer cells is altered by osteoblast-derived growth factors 

      Koutsilieris, M.; Reyes-Moreno, C.; Choki, I.; Sourla, A.; Doillon, C.; Pavlidis, Nicholas (1999)
      One-third of women with breast cancer will develop bone metastases and eventually die from disease progression at these sites. Therefore, we analyzed the ability of human MG-63 osteoblast-like cells (MG-63 cells), MG- 63 ...
    • Article  

      Direct evidence for normalization of platelet function resulting from platelet count reduction in essential thrombocythemia 

      Tsantes, Argirio E.; Nikolopoulos, Georgios K.; Tsirigotis, P.; Zoi, K.; Zomas, A.; Kapsimali, Violetta; Kopterides, Petros; Chondropoulos, Spyros; Dervenoulas, John; Mantzios, Georgios P. (2011)
      Essential thrombocythemia is characterized by persistent elevation and functional disturbances of platelets. Both the platelet function analyzer-100 (PFA-100) collagen-epinephrine (CEPI) cartridge and aggregometry with ...
    • Article  

      Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis 

      Nikolopoulos, Georgios K.; Tsantes, Argirio E.; Bagos, Pantelis G.; Travlou, Anthi S.; Vaiopoulos, G. (2007)
      Introduction: Platelet adhesion to fibrillar collagen via the membrane glycoprotein (GP) Ia/IIa (α2β1), is a crucial event in the pathogenesis of arterial occlusive disorders. The C807T single nucleotide polymorphism of ...
    • Article  

      Microstructure-based, multiscale modeling for the mechanical behavior of hydrated fiber networks 

      Barocas, V. Η; Chandran, P. L.; Stylianopoulos, T. (2008)
      A multiscale formulation is derived for the mechanics of a dilute fiber network microstructure, as occurs in in vitro reconstituted collagen gels, to accommodate the deterministic solution of a uniform-stress condition in ...
    • Doctoral Thesis  Open Access

      Molecular genetic investigation, epidemiology and genotype-phenotype correlation in familial microscopic hematuria 

      Demosthenous, Panagiota (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2012-05)
      Η παρούσα διατριβή έχει επικεντρωθεί στη διερεύνηση εμπλοκής γνωστών γονιδίων του κολλαγόνου τύπου IV της βασικής μεμβράνης του σπειράματος (COL4A4, COL4A5) καθώς και στην έρευνα για νέα γονίδια που συνδέονται με Οικογενή ...
    • Article  

      Multiscale computation for bioartificial soft tissues with complex geometries 

      Barocas, V. Η; Luo, X.-J.; Stylianopoulos, T.; Shephard, M. S. (2009)
      The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This ...
    • Article  

      Multiscale modelling of solid tumour growth: the effect of collagen micromechanics 

      Wijeratne, P. A.; Vavourakis, V.; Hipwell, J. H.; Voutouri, C.; Papageorgis, P.; Stylianopoulos, T.; Evans, A.; Hawkes, D. J. (2016)
      Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
    • Article  

      Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...
    • Article  

      Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy 

      Mpekris, F.; Papageorgis, P.; Polydorou, C.; Voutouri, C.; Kalli, M.; Pirentis, A. P.; Stylianopoulos, T. (2017)
      Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
    • Conference Object  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Stylianopoulos, T.; Calvin, S. E.; Cook, R. F. (Affiliation: Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Minnesota Perinatal Physicians/Allina Health System, Minneapolis, MN 55407, United StatesCorrespondence Address: Oyen, M.L.Department of Biophysical Sciences and Medical Physics, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
      Chorioamnion, the membrane surrounding a fetus during gestation (the "amniotic sac"), is a structural soft tissue for which the mechanical behavior is poorly understood-despite its critical role in maintaining a successful ...
    • Article  

      Uniaxial and biaxial mechanical behavior of human amnion 

      Barocas, V. Η; Oyen, M. L.; Cook, R. F.; Stylianopoulos, T.; Calvin, S. E.; Landers, D. V. (2005)
      Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly ...
    • Article  

      Volume-averaging theory for the study of the mechanics of collagen networks 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      A multiscale methodology has been developed for modeling mechanical behavior of collagen fiber networks. The methodology addresses scale separation between the macroscopic, tissue-level scale and the microscopic, fiber-level ...
    • Doctoral Thesis  Open Access

      Η γενετική διερεύνηση των νεφροπαθειών κολλαγόνου IV στον πληθυσμό Κύπρου και Ελλάδας με συμβατικές προσεγγίσεις και με αλληλούχηση επόμενης γενεάς 

      Παπαζαχαρίου, Λουϊζα Ζ. (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2015-05)
      Η Οικογενής Μικροσκοπική Αιματουρία (ΟΜΑ) αποτελεί μία γενετικά ετερογενή ομάδα παθήσεων που συμπεριλαμβάνουν κληρονομικές σπειραματοπάθειες, όπως το σύνδρομο Alport και τη Νεφροπάθεια της Λεπτής Βασικής Μεμβράνης (ΝΛΒΜ). ...