dc.contributor.author | Varras, M. | en |
dc.contributor.author | Skafida, E. | en |
dc.contributor.author | Vasilakaki, T. | en |
dc.contributor.author | Anastasiadis, A. | en |
dc.contributor.author | Akrivis, C. | en |
dc.contributor.author | Vrachnis, N. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.creator | Varras, M. | en |
dc.creator | Skafida, E. | en |
dc.creator | Vasilakaki, T. | en |
dc.creator | Anastasiadis, A. | en |
dc.creator | Akrivis, C. | en |
dc.creator | Vrachnis, N. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.date.accessioned | 2018-06-22T09:53:25Z | |
dc.date.available | 2018-06-22T09:53:25Z | |
dc.date.issued | 2013 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41831 | |
dc.description.abstract | Introduction: Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. Aim: The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors. Materials and Methods: Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-μm-thick sections. Results: The mean age of patients was 65 years (± 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested. Conclusions: The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters. | en |
dc.language.iso | eng | en |
dc.source | European journal of gynaecological oncology | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Female | en |
dc.subject | Middle aged | en |
dc.subject | Clinical article | en |
dc.subject | Human tissue | en |
dc.subject | Prognosis | en |
dc.subject | Cancer prognosis | en |
dc.subject | Carcinoma | en |
dc.subject | Protein expression | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Tumor differentiation | en |
dc.subject | Cancer grading | en |
dc.subject | Histopathology | en |
dc.subject | Cancer invasion | en |
dc.subject | Uvomorulin | en |
dc.subject | Protein localization | en |
dc.subject | Endometrial neoplasms | en |
dc.subject | Cadherins | en |
dc.subject | Pathology | en |
dc.subject | E-cadherin | en |
dc.subject | Endometrial | en |
dc.subject | Endometrioid | en |
dc.subject | Endometrium carcinoma | en |
dc.subject | Tumor necrosis | en |
dc.title | Expression of E-cadherin in primary endometrial carcinomas: Clinicopathological and immunohistochemical analysis of 30 cases | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 34 | |
dc.description.issue | 1 | |
dc.description.startingpage | 31 | |
dc.description.endingpage | 35 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |