Phase II studies of Elsamitrucin in breast cancer, colorectal cancer, non-small cell lung cancer and ovarian cancer
dc.contributor.author | Verweij, J. | en |
dc.contributor.author | Wanders, J. | en |
dc.contributor.author | Nielsen, A. L. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Calabresi, F. | en |
dc.contributor.author | Huinink, W. T. B. | en |
dc.contributor.author | Bruntsch, U. | en |
dc.contributor.author | Piccart, M. | en |
dc.contributor.author | Franklin, H. R. | en |
dc.contributor.author | Kaye, Stanley B. | en |
dc.creator | Verweij, J. | en |
dc.creator | Wanders, J. | en |
dc.creator | Nielsen, A. L. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Calabresi, F. | en |
dc.creator | Huinink, W. T. B. | en |
dc.creator | Bruntsch, U. | en |
dc.creator | Piccart, M. | en |
dc.creator | Franklin, H. R. | en |
dc.creator | Kaye, Stanley B. | en |
dc.date.accessioned | 2018-06-22T09:53:26Z | |
dc.date.available | 2018-06-22T09:53:26Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41832 | |
dc.description.abstract | Purpose: To test the antitumor activity of Elsamitrucin in metastatic cancer of the breast, colon and rectum, non-small cell lung and ovary. Patients and methods: Eligibility required histologically proven cancer. Patients with colorectal or non-small cell lung cancer could not have received prior chemotherapy. Patients were entered if WHO PS was ≤2 and organ functions were normal. Treatment consisted of Elsamitrucin 25 mg/m2/week given as a 5-10 min infusion for at least 3-6 weekly doses. Results: One hundred and five patients entered the studies, 97 were eligible, 94 are evaluable for toxicity and 75 for response. Toxicity mainly consisted of mild nausea/vomiting, and less frequently reversible hepatotoxicity and malaise. No objective responses were seen. Conclusion: Elsamitrucin at this dose and schedule is not an active drug in metastatic breast cancer, colorectal cancer, non-small cell lung cancer or ovarian cancer. © 1994 Kluwer Academic Publishers. | en |
dc.language.iso | eng | en |
dc.source | Annals of Oncology | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Neoplasms | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Breast cancer | en |
dc.subject | Breast neoplasms | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Ovarian neoplasms | en |
dc.subject | Ovary cancer | en |
dc.subject | Priority journal | en |
dc.subject | Clinical trial | en |
dc.subject | Phase 2 clinical trial | en |
dc.subject | Drug administration schedule | en |
dc.subject | Liver toxicity | en |
dc.subject | Lung neoplasms | en |
dc.subject | Lung non small cell cancer | en |
dc.subject | Colorectal cancer | en |
dc.subject | Carcinoma | en |
dc.subject | Malaise | en |
dc.subject | Male | en |
dc.subject | Intravenous drug administration | en |
dc.subject | Vomiting | en |
dc.subject | Follow-up studies | en |
dc.subject | Colorectal neoplasms | en |
dc.subject | Nausea | en |
dc.subject | Antineoplastic | en |
dc.subject | Middle age | en |
dc.subject | Phase ii | en |
dc.subject | Non-small-cell lung | en |
dc.subject | Adolescent | en |
dc.subject | Antibiotics | en |
dc.subject | Breast | en |
dc.subject | Aminoglycoside | en |
dc.subject | Colorectum | en |
dc.subject | Elsamicin a | en |
dc.subject | Elsamitrucin | en |
dc.subject | Nonsmall cell lung | en |
dc.subject | Ovary | en |
dc.title | Phase II studies of Elsamitrucin in breast cancer, colorectal cancer, non-small cell lung cancer and ovarian cancer | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 5 | |
dc.description.issue | 4 | |
dc.description.startingpage | 375 | |
dc.description.endingpage | 376 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 |
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