dc.contributor.author | Yiallouros, Panayiotis K. | en |
dc.contributor.author | Savva, Savvas C. | en |
dc.contributor.author | Kolokotroni, Ourania | en |
dc.contributor.author | Behbod, B. | en |
dc.contributor.author | Zenios, Michalis | en |
dc.contributor.author | Economou, Mary | en |
dc.contributor.author | Chadjigeorgiou, C. | en |
dc.contributor.author | Kourides, Y. A. | en |
dc.contributor.author | Tornaritis, M. J. | en |
dc.contributor.author | Lamnisos, Demetris | en |
dc.contributor.author | Middleton, Nicos | en |
dc.contributor.author | Milton, Donald K. | en |
dc.creator | Yiallouros, Panayiotis K. | en |
dc.creator | Savva, Savvas C. | en |
dc.creator | Kolokotroni, Ourania | en |
dc.creator | Behbod, B. | en |
dc.creator | Zenios, Michalis | en |
dc.creator | Economou, Mary | en |
dc.creator | Chadjigeorgiou, C. | en |
dc.creator | Kourides, Y. A. | en |
dc.creator | Tornaritis, M. J. | en |
dc.creator | Lamnisos, Demetris | en |
dc.creator | Middleton, Nicos | en |
dc.creator | Milton, Donald K. | en |
dc.date.accessioned | 2018-06-22T09:53:27Z | |
dc.date.available | 2018-06-22T09:53:27Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41846 | |
dc.description.abstract | Background: Whilst emerging evidence from animal and cell experiments has shown high-density lipoprotein cholesterol to have anti-inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of high-density lipoprotein cholesterol with asthma have produced conflicting results. Objective: To examine the association between serum lipids among Cypriot children aged 11-12 years and prevalence of asthma at age 15-17 years. Methods: In 3982 children, we assessed serum lipids, body mass index and maximal oxygen consumption at baseline (2001-2003) and explored associations with respiratory health at follow-up (2007) using multiple logistic regression models. Results: Lower levels of high-density lipoprotein cholesterol at age 11-12 years were found in subjects who reported ever asthma (58.2 vs. 60.0 mg/dL, P = 0.005) and active asthma (57.5 vs. 59.9 mg/dL, P = 0.010) in adolescence, in comparison with their respective reference groups. Total cholesterol, low-density lipoprotein and triglycerides had no association with any of the asthma outcomes. In contrast, with estimated odds ratios of 1.89 (95% CI 1.19-3.00) and 1.89 (95% CI 1.02-3.53), ever asthma and active asthma respectively appeared particularly pronounced among those who at baseline had high-density lipoprotein cholesterol <40 mg/dL, even after adjusting for potential confounders including body mass index and maximal oxygen consumption. Conclusions & Clinical Relevance: Low-serum high-density lipoprotein cholesterol in childhood is associated with an increased risk for asthma in adolescence, suggesting a potential role of this lipoprotein in the pathogenesis of paediatric asthma. © 2011 Blackwell Publishing Ltd. | en |
dc.language.iso | eng | en |
dc.source | Clinical and Experimental Allergy | en |
dc.subject | Asthma | en |
dc.subject | Adolescents | en |
dc.subject | Adiposity | en |
dc.subject | High-density lipoprotein cholesterol | en |
dc.subject | Physical fitness. | en |
dc.title | Low serum high-density lipoprotein cholesterol in childhood is associated with adolescent asthma | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/j.1365-2222.2011.03940.x | |
dc.description.volume | 42 | |
dc.description.issue | 3 | |
dc.description.startingpage | 423 | |
dc.description.endingpage | 432 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Yiallouros, Panayiotis K. [0000-0002-8339-9285] | |
dc.contributor.orcid | Kolokotroni, Ourania [0000-0002-7653-002X] | |
dc.contributor.orcid | Lamnisos, Demetris [0000-0001-8535-6601] | |
dc.contributor.orcid | Milton, Donald K. [0000-0002-0550-7834] | |
dc.gnosis.orcid | 0000-0002-8339-9285 | |
dc.gnosis.orcid | 0000-0002-7653-002X | |
dc.gnosis.orcid | 0000-0001-8535-6601 | |
dc.gnosis.orcid | 0000-0002-0550-7834 | |