Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review
Date
2016Author
Zarkavelis, GeorgeKollas, Aristomenes
Kampletsas, E. O.
Vasiliou, V.
Kaltsonoudis, E.
Drosos, Alexandros A.
Khaled, H.
Pavlidis, Nicholas
Source
Journal of Advanced ResearchVolume
7Issue
5Pages
719-726Google Scholar check
Keyword(s):
Metadata
Show full item recordAbstract
Subacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated with the taxanes being the most common anticancer agents. However, recent data emerging point toward antiestrogen therapies as a causative factor not only for SCLE but also for a variety of autoimmune disorders. This is a report of a case of a 42 year old woman who developed clinical manifestations of SCLE after letrozole treatment in whom remission of the cutaneous manifestations was noticed upon discontinuation of the drug. In addition, an extensive review of the English literature has been performed regarding the association of antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should be aware of the potential development of autoimmune reactions in breast cancer patients treated with aromatase inhibitors. © 2016