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dc.contributor.authorIoachim, E.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorBatsis, Chen
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorAgnantis, Niki J.en
dc.creatorIoachim, E.en
dc.creatorCharchanti, A.en
dc.creatorBriassoulis, E. Chen
dc.creatorKaravasilis, V.en
dc.creatorBatsis, Chen
dc.creatorPavlidis, Nicholasen
dc.creatorAgnantis, Niki J.en
dc.date.accessioned2018-06-22T09:53:41Z
dc.date.available2018-06-22T09:53:41Z
dc.date.issued2002
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41965
dc.description.abstractThe formation of new vessels in both primary tumour and in metastasis induce various growth factors included the vascular endothelial growth factors (VEGF). The immunohistochemical expression of vascular endothelial growth factor (VEGF) in correlation with microvessel density (MVD) and other clinicopathological parameters was studied in breast carcinomas. This study was performed on a series of paraffin sections from 160 invasive breast cancer specimens by immunohistochemistry using the streptavidin-biotin method. The combination of extension and intensity of immunostaining was evaluated. VEGF expression was found in 151/160 (94.4%) of the cases. A statistically significant positive relationship between VEGF expression with grade of differentiation (p=0.003) and lymph node metastases (p=0.026) was found. In addition, high level of VEGF was correlated with negative estrogen receptor status (p=0.034). Patients with high VEGF expression showed a better response to treatment (p=0.04). No correlation between VEGF expression and MVD was found. These results showed that VEGF could be considered as poor prognostic factor in invasive breast carcinomas. In addition, its expression may be useful for clinical therapeutic application.en
dc.language.isoengen
dc.sourceElectronic Journal of Pathology and Histologyen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectControlled studyen
dc.subjectMajor clinical studyen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectHuman tissueen
dc.subjectStatistical analysisen
dc.subjectPathogenesisen
dc.subjectCorrelation analysisen
dc.subjectProtein expressionen
dc.subjectImmunohistochemistryen
dc.subjectProtein p53en
dc.subjectBreast canceren
dc.subjectBreast carcinomaen
dc.subjectVasculotropinen
dc.subjectHuman cellen
dc.subjectCell differentiationen
dc.subjectMicrovasculatureen
dc.subjectVegfen
dc.titleThe prognostic value of vascular endothelial growth factor (VEGF) in invasive breast cancer: Correlation with microvessel density (MVD), ER, PgR, p53 and proliferative associated indices (Ki-67, PCNA)en
dc.typeinfo:eu-repo/semantics/article
dc.description.volume8
dc.description.issue4
dc.description.startingpage24071
dc.description.endingpage2400710
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidKaravasilis, V. [0000-0002-5806-9399]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-5806-9399


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