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dc.contributor.authorIoachim, E.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorArvanitis, D. L.en
dc.contributor.authorAgnantis, Niki J.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorIoachim, E.en
dc.creatorCharchanti, A.en
dc.creatorBriassoulis, E. Chen
dc.creatorKaravasilis, V.en
dc.creatorTsanou, E.en
dc.creatorArvanitis, D. L.en
dc.creatorAgnantis, Niki J.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:41Z
dc.date.available2018-06-22T09:53:41Z
dc.date.issued2002
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41966
dc.description.abstractThe immunohistochemical expression of the extracellular matrix (ECM) components tenascin (TN), fibronectin (FN), collagen type IV (Coll) and laminin (LN), and their possible relationships were studied in a series of 134 operable breast cancer cases. Their expression was also compared with the expression of the proteolytic enzyme cathepsin D (CD), the adhesion molecule CD44 standard form (CD44s) and other known factors to clarify the prognostic value and role of these molecules in tumour progression and metastasis. TN expression in the tumour stroma was positively correlated with tumour grade and size, CD44s expression, tumour and stromal CD expression as well as with FN, laminin and Coll expression in the same areas. TN expression was inverse correlated with ER status. Its expression at the invasion front was only positively correlated with the lymph node status. Survival analysis showed an increased mortality risk associated with high levels of TN expression. In multivariate analysis, among the ECM proteins, only TN expression was independently correlated with patients' survival. FN expression was positively correlated with lymph node involvement, with the proliferation-associated index Ki-67 and stromal CD expression. Survival analysis showed an increased mortality risk associated with a high level of FN expression. Coll expression was positively correlated with the tumour size and LN expression. An inverse relationship of Coll expression with ER and PgR receptor status was also found. LN expression was positively correlated with tumour and stromal CD expression, with the proliferation-associated index Ki-67 and inversely with ER receptor status. The observed alterations in the expression of ECM proteins in breast cancer tissue and their correlations with the proteolytic enzyme CD and the adhesion molecule CD44s, suggest an involvement in cancer progression. In addition, overexpression of stromal TN and FN seems to have negative prognostic value in breast cancer patients. © 2002 Elsevier Science Ltd. All rights reserved.en
dc.language.isoengen
dc.sourceEuropean journal of canceren
dc.subjectArticleen
dc.subjectHumanen
dc.subject80 and overen
dc.subjectAgeden
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast neoplasmsen
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectCancer growthen
dc.subjectCancer survivalen
dc.subjectDisease progressionen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectHuman tissueen
dc.subjectSurvival analysisen
dc.subjectCancer mortalityen
dc.subjectAntigensen
dc.subjectCden
dc.subjectCorrelation analysisen
dc.subjectImmunohistochemistryen
dc.subjectProtein expressionen
dc.subjectNeoplasm invasivenessen
dc.subjectBreast canceren
dc.subjectBreast carcinomaen
dc.subjectCancer gradingen
dc.subjectEstrogen receptoren
dc.subjectProgesterone receptoren
dc.subjectCancer sizeen
dc.subjectNeoplasm proteinsen
dc.subjectKi 67 antigenen
dc.subjectLymph nodeen
dc.subjectCancer invasionen
dc.subjectCathepsinen
dc.subjectCathepsin den
dc.subjectCd44sen
dc.subjectCohort studiesen
dc.subjectCollagen iven
dc.subjectCollagen type 4en
dc.subjectExtracellular matrixen
dc.subjectFibronectinen
dc.subjectFibronectinsen
dc.subjectHermes antigenen
dc.subjectLamininen
dc.subjectScleroproteinen
dc.subjectTenascinen
dc.titleImmunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: Their prognostic value and role in tumour invasion and progressionen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/S0959-8049(02)00210-1
dc.description.volume38
dc.description.issue18
dc.description.startingpage2362
dc.description.endingpage2370
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidKaravasilis, V. [0000-0002-5806-9399]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-5806-9399


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