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dc.contributor.authorKamposioras, K.en
dc.contributor.authorPentheroudakis, Georgeen
dc.contributor.authorPectasides, Dimitriosen
dc.contributor.authorPavlidis, Nicholasen
dc.creatorKamposioras, K.en
dc.creatorPentheroudakis, Georgeen
dc.creatorPectasides, Dimitriosen
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:44Z
dc.date.available2018-06-22T09:53:44Z
dc.date.issued2011
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41993
dc.description.abstractIntroduction: Although more than 90% of melanomas have a cutaneous origin, occasionally it is discovered as a secondary deposit without evident primary site. The aim of this study was to systematically review published literature and analyse data on incidence, presentation, therapeutic interventions, survival and prognostic factors. Methods: We searched MEDLINE, (search terms Melanom*, unknown origin, unknown primary, indolent, occult) and the abstracts from major congresses of the last 4 years and perused the references of the retrieved relevant articles. Results: 4348 patients with MUP were reported along with 132,. 643 patients with Melanoma of Known Primary (MKP). The incidence of MUP was 3.2%. The male to female ratio was 2:1 while the age peak was in the 4th and 5th decades. MUP patients harbouring nodal disease had a median overall survival ranging between 24 and 127 months, 5-year survival rate between 28.6% and 75.6% and 10-year survival rate between 18.8% and 62.9%. MUP patients with visceral disease had median survival times between 3 and 16 months, and 5-year survival rates between 5.9% and 18%. Presence of tumour regression in metastatic sites and low nodal burden were associated with favourable outcome. Potentially curative surgical treatment offered survival advantage in comparison to patients with residual metastatic foci. MUP patients who received adjuvant chemotherapy or radiotherapy paradoxically seemed to fare worse compared to patients observed. Conclusions: This is the first review to bring together the information of 89 years and to analyze all the potential information accumulated. Although a well know entity no consensus is reached in order to describe MUP presentation, management or prognosis. © 2010 Elsevier Ireland Ltd.en
dc.language.isoengen
dc.sourceCritical reviews in oncology/hematologyen
dc.subjectCisplatinen
dc.subjectCyclophosphamideen
dc.subjectDacarbazineen
dc.subjectDactinomycinen
dc.subjectEtoposideen
dc.subjectHumanen
dc.subjectMethotrexateen
dc.subjectProcarbazineen
dc.subjectVincristineen
dc.subjectHumansen
dc.subjectCancer survivalen
dc.subjectNeoplasm stagingen
dc.subjectRecurrenceen
dc.subjectPrognosisen
dc.subjectReviewen
dc.subjectNeoplasm metastasisen
dc.subjectOutcome assessmenten
dc.subjectSurvivalen
dc.subjectAlpha interferonen
dc.subjectCancer radiotherapyen
dc.subjectMelphalanen
dc.subjectSystematic reviewen
dc.subjectCarmustineen
dc.subjectLomustineen
dc.subjectMelanomaen
dc.subjectCancer adjuvant therapyen
dc.subjectLymph node metastasisen
dc.subjectCancer incidenceen
dc.subjectDisease associationen
dc.subjectSpontaneousen
dc.subjectIncidenceen
dc.subjectCancer of unknown primary siteen
dc.subjectVisceral metastasisen
dc.subjectCancer regressionen
dc.subjectInterleukin 2en
dc.subjectUnknown primaryen
dc.subjectTumor regressionen
dc.subjectGeographic distributionen
dc.subjectSemustineen
dc.subjectEstramustineen
dc.subjectFamily historyen
dc.subjectInformation processingen
dc.subjectNeoplasm regressionen
dc.subjectOcculten
dc.subjectScientific literatureen
dc.subjectSkin metastasisen
dc.subjectThiotepaen
dc.titleMalignant melanoma of unknown primary site. To make the long story short. A systematic review of the literatureen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.critrevonc.2010.04.007
dc.description.volume78
dc.description.issue2
dc.description.startingpage112
dc.description.endingpage126
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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