dc.contributor.author | Kiriakogiani-Psaropoulou, P. | en |
dc.contributor.author | Malamou-Mitsi, Vassiliki D. | en |
dc.contributor.author | Martinopoulou, U. | en |
dc.contributor.author | Legaki, S. | en |
dc.contributor.author | Tamvakis, N. | en |
dc.contributor.author | Vrettou, E. | en |
dc.contributor.author | Fountzilas, George | en |
dc.contributor.author | Skarlos, Dimosthenis V. | en |
dc.contributor.author | Kosmidis, Paraskevas A. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.creator | Kiriakogiani-Psaropoulou, P. | en |
dc.creator | Malamou-Mitsi, Vassiliki D. | en |
dc.creator | Martinopoulou, U. | en |
dc.creator | Legaki, S. | en |
dc.creator | Tamvakis, N. | en |
dc.creator | Vrettou, E. | en |
dc.creator | Fountzilas, George | en |
dc.creator | Skarlos, Dimosthenis V. | en |
dc.creator | Kosmidis, Paraskevas A. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.date.accessioned | 2018-06-22T09:53:47Z | |
dc.date.available | 2018-06-22T09:53:47Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42021 | |
dc.description.abstract | In order to estimate the value of immunohistochemical identification of neuroendocrine (NE) differentiation markers in non-small cell lung carcinomas (NSCLCs), we investigated the expression of five neuroendocrine and neural differentiation-related antigens in 51 NSCLCs. Additionally, 20 epithelial lung tumors with NE differentiation [15 carcinoids and five small cell lung carcinomas (SCLCs)] and 61 epithelial tumors of various other origin (breast, prostate, colon and head-neck carcinomas) were studied. An indirect two-stage immunoperoxidase method was performed in formalin-fixed and paraffin-embedded tissue specimens, by using commercially available monoclonal antibodies. These antibodies are directed against neuron-specific enolase (NSE), chromogranin-A and Leu-7 which are general markers of NE differentiation, bombesin, which is a specific NE secretory product and neurofilament triplet protein (NFTP), an intermediate filament protein of neuronal differentiation. All five markers demonstrated a positive immunoreactivity in NSCLCs, equally distributed to all three histologic subtypes, ranging from 16 to 47% of the cases (NSE 47%, bombesin 21.5%, Leu-7 21.5%, chromogranin-A 18% and NFTP 16%). Most of the carcinoids and SCLCs expressed multiple or all NE markers. The other four epithelial tumors showed a positive immunoreactivity for bombesin, Leu-7 and NFTP, ranging from 11 to 40% of the cases. Chromogranin-A was not expressed in any of these tumors, whereas NSE was demonstrated only in 17% of breast carcinomas. The following remarks can be drawn from this study: (1) some NSCLCs showed immunophenotypic NE differentiation; (2) among all the markers used, NSE was the most sensitive (sensitivity, 100%) and chromogranin-A the most specific (specificity, 100%); and (3) NSE and chromogranin-A appear to be the most valuable and useful indicators of probable neuroendocrine differentiation in lung epithelial tumors. © 1994. | en |
dc.language.iso | eng | en |
dc.source | Lung Cancer | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Major clinical study | en |
dc.subject | Priority journal | en |
dc.subject | Human tissue | en |
dc.subject | Lung neoplasms | en |
dc.subject | Lung non small cell cancer | en |
dc.subject | Carcinoma | en |
dc.subject | Antigens | en |
dc.subject | Cd | en |
dc.subject | Differentiation | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Biological | en |
dc.subject | Tumor markers | en |
dc.subject | Tumor marker | en |
dc.subject | Neuroendocrine tumor | en |
dc.subject | Non-small-cell lung | en |
dc.subject | Neuron specific enolase | en |
dc.subject | Phosphopyruvate hydratase | en |
dc.subject | Bombesin | en |
dc.subject | Cd57 | en |
dc.subject | Chromogranin a | en |
dc.subject | Chromogranin-a | en |
dc.subject | Chromogranins | en |
dc.subject | Immunoenzyme techniques | en |
dc.subject | Leu-7 | en |
dc.subject | Neuroendocrine markers | en |
dc.subject | Neurofilament proteins | en |
dc.subject | Nftp | en |
dc.subject | Nsclc | en |
dc.subject | Nse | en |
dc.subject | T-lymphocyte | en |
dc.title | The value of neuroendocrine markers in non-small cell lung cancer: a comparative immunohistopathologic study | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/0169-5002(94)92164-4 | |
dc.description.volume | 11 | |
dc.description.issue | 5-6 | |
dc.description.startingpage | 353 | |
dc.description.endingpage | 364 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |