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dc.contributor.authorKiriakogiani-Psaropoulou, P.en
dc.contributor.authorMalamou-Mitsi, Vassiliki D.en
dc.contributor.authorMartinopoulou, U.en
dc.contributor.authorLegaki, S.en
dc.contributor.authorTamvakis, N.en
dc.contributor.authorVrettou, E.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorSkarlos, Dimosthenis V.en
dc.contributor.authorKosmidis, Paraskevas A.en
dc.contributor.authorPavlidis, Nicholasen
dc.creatorKiriakogiani-Psaropoulou, P.en
dc.creatorMalamou-Mitsi, Vassiliki D.en
dc.creatorMartinopoulou, U.en
dc.creatorLegaki, S.en
dc.creatorTamvakis, N.en
dc.creatorVrettou, E.en
dc.creatorFountzilas, Georgeen
dc.creatorSkarlos, Dimosthenis V.en
dc.creatorKosmidis, Paraskevas A.en
dc.creatorPavlidis, Nicholasen
dc.date.accessioned2018-06-22T09:53:47Z
dc.date.available2018-06-22T09:53:47Z
dc.date.issued1994
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42021
dc.description.abstractIn order to estimate the value of immunohistochemical identification of neuroendocrine (NE) differentiation markers in non-small cell lung carcinomas (NSCLCs), we investigated the expression of five neuroendocrine and neural differentiation-related antigens in 51 NSCLCs. Additionally, 20 epithelial lung tumors with NE differentiation [15 carcinoids and five small cell lung carcinomas (SCLCs)] and 61 epithelial tumors of various other origin (breast, prostate, colon and head-neck carcinomas) were studied. An indirect two-stage immunoperoxidase method was performed in formalin-fixed and paraffin-embedded tissue specimens, by using commercially available monoclonal antibodies. These antibodies are directed against neuron-specific enolase (NSE), chromogranin-A and Leu-7 which are general markers of NE differentiation, bombesin, which is a specific NE secretory product and neurofilament triplet protein (NFTP), an intermediate filament protein of neuronal differentiation. All five markers demonstrated a positive immunoreactivity in NSCLCs, equally distributed to all three histologic subtypes, ranging from 16 to 47% of the cases (NSE 47%, bombesin 21.5%, Leu-7 21.5%, chromogranin-A 18% and NFTP 16%). Most of the carcinoids and SCLCs expressed multiple or all NE markers. The other four epithelial tumors showed a positive immunoreactivity for bombesin, Leu-7 and NFTP, ranging from 11 to 40% of the cases. Chromogranin-A was not expressed in any of these tumors, whereas NSE was demonstrated only in 17% of breast carcinomas. The following remarks can be drawn from this study: (1) some NSCLCs showed immunophenotypic NE differentiation; (2) among all the markers used, NSE was the most sensitive (sensitivity, 100%) and chromogranin-A the most specific (specificity, 100%); and (3) NSE and chromogranin-A appear to be the most valuable and useful indicators of probable neuroendocrine differentiation in lung epithelial tumors. © 1994.en
dc.language.isoengen
dc.sourceLung Canceren
dc.subjectArticleen
dc.subjectHumanen
dc.subjectMajor clinical studyen
dc.subjectPriority journalen
dc.subjectHuman tissueen
dc.subjectLung neoplasmsen
dc.subjectLung non small cell canceren
dc.subjectCarcinomaen
dc.subjectAntigensen
dc.subjectCden
dc.subjectDifferentiationen
dc.subjectImmunohistochemistryen
dc.subjectBiologicalen
dc.subjectTumor markersen
dc.subjectTumor markeren
dc.subjectNeuroendocrine tumoren
dc.subjectNon-small-cell lungen
dc.subjectNeuron specific enolaseen
dc.subjectPhosphopyruvate hydrataseen
dc.subjectBombesinen
dc.subjectCd57en
dc.subjectChromogranin aen
dc.subjectChromogranin-aen
dc.subjectChromograninsen
dc.subjectImmunoenzyme techniquesen
dc.subjectLeu-7en
dc.subjectNeuroendocrine markersen
dc.subjectNeurofilament proteinsen
dc.subjectNftpen
dc.subjectNsclcen
dc.subjectNseen
dc.subjectT-lymphocyteen
dc.titleThe value of neuroendocrine markers in non-small cell lung cancer: a comparative immunohistopathologic studyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/0169-5002(94)92164-4
dc.description.volume11
dc.description.issue5-6
dc.description.startingpage353
dc.description.endingpage364
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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