Show simple item record

dc.contributor.authorKolokotroni, Ouraniaen
dc.contributor.authorPapadopoulou, A.en
dc.contributor.authorMiddleton, Nicosen
dc.contributor.authorKouta, Christianaen
dc.contributor.authorRaftopoulos, V.en
dc.contributor.authorNicolaidou, P.en
dc.contributor.authorYiallouros, Panayiotis K.en
dc.creatorKolokotroni, Ouraniaen
dc.creatorPapadopoulou, A.en
dc.creatorMiddleton, Nicosen
dc.creatorKouta, Christianaen
dc.creatorRaftopoulos, V.en
dc.creatorNicolaidou, P.en
dc.creatorYiallouros, Panayiotis K.en
dc.date.accessioned2018-06-22T09:53:48Z
dc.date.available2018-06-22T09:53:48Z
dc.date.issued2015
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42029
dc.description.abstractBackground: Emerging evidence suggests that vitamin D might be implicated in asthma pathophysiology. This study aims to compare Vitamin D mean serum levels and status between asthmatic and non-asthmatic adolescents and investigate the association of vitamin D with asthma severity. Methods: In a cohort of adolescents aged 16-17 years, those reporting wheezing in the past 12 months and Ever asthma on the ISAAC questionnaire were invited to participate and formed the Active Asthmatics group. Controls were selected amongst Never Wheezers/Never Asthmatics (NWNA). Differences in mean 25(OH)D serum levels and vitamin D status between AA and NWNA were examined in multivariate linear and logistic regression models respectively, adjusting for potential confounders. Within AA, differences in vitamin D levels were assessed across asthma severity indicators. Results: A total of 69 AA and 671 NWNA participated in the study. Unadjusted mean 25(OH)D serum levels were 22.90 (SD 6.41), and 21.15 (SD 5.59) ng/mL in NWNA and AA respectively (p = 0.03). In adjusted models, mean 25(OH)D levels remained significantly lower amongst AA compared to NWNA (adjusted beta coefficient -1.68, 95% CI -3.24, -0.13). Severe (<12 ng/mL), moderate (<25 ng/mL) or insufficient (<30 ng/mL) vitamin D status was more prevalent among AA who were 1.6 times (95% CI 1.01, 2.53) more likely to belong to a lower vitamin D category compared to NWNA. Within AA, there was a negative trend between vitamin D levels and the number of reported asthma severity indicators. Conclusions: Levels of vitamin D tend to be lower among asthmatic compared to non-asthmatic children and in those with severe asthma independent of important confounders. © 2015 Kolokotroni et al.en
dc.language.isoengen
dc.sourceBMC Public Healthen
dc.subjectAsthmaen
dc.subjectAdolescentsen
dc.subjectAsthma severityen
dc.subjectVitamin d levelsen
dc.subjectVitamin d statusen
dc.titleVitamin D levels and status amongst asthmatic and non-asthmatic adolescents in Cyprus: A comparative cross-sectional studyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s12889-015-1385-2
dc.description.volume15
dc.description.issue1
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidYiallouros, Panayiotis K. [0000-0002-8339-9285]
dc.contributor.orcidKolokotroni, Ourania [0000-0002-7653-002X]
dc.gnosis.orcid0000-0002-8339-9285
dc.gnosis.orcid0000-0002-7653-002X


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record