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Laboratory Assessment of the Anticoagulant Activity of Dabigatran

dc.contributor.authorKyriakou, Eliasen
dc.contributor.authorIkonomidis, Ignatiosen
dc.contributor.authorStylos, D.en
dc.contributor.authorBonovas, Stefanosen
dc.contributor.authorPapadakis, I.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorKokoris, Stylianien
dc.contributor.authorKalantzis, Dimitriosen
dc.contributor.authorEconomopoulou, Christineen
dc.contributor.authorKopterides, Petrosen
dc.contributor.authorLekakis, Johnen
dc.contributor.authorTsantes, Argirio E.en
dc.creatorKyriakou, Eliasen
dc.creatorIkonomidis, Ignatiosen
dc.creatorStylos, D.en
dc.creatorBonovas, Stefanosen
dc.creatorPapadakis, I.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorKokoris, Stylianien
dc.creatorKalantzis, Dimitriosen
dc.creatorEconomopoulou, Christineen
dc.creatorKopterides, Petrosen
dc.creatorLekakis, Johnen
dc.creatorTsantes, Argirio E.en
dc.date.accessioned2018-06-22T09:53:57Z
dc.date.available2018-06-22T09:53:57Z
dc.date.issued2015
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42115
dc.description.abstractBackground: Our aim was to identify laboratory assays in order to assess the anticoagulant effects of dabigatran etexilate (DE). Methods: Twenty patients with nonvalvular atrial fibrillation treated on DE (110 mg per os twice daily) and 20 on acenocoumarol were studied. Conventional coagulation tests, endogenous thrombin potential (ETP), thromboelastometry (ROTEM), epinephrine-induced light transmission aggregometry (LTA), and Hemoclot Thrombin Inhibitors (HTI) were performed in all patients. Results: In ROTEM analysis, the lysis index at 60 minutes was significantly lower in patients receiving DE (P = .011). In LTA, patients on DE showed decreased aggregation compared to those on acenocoumarol, marginally insignificant (P = .068). Regarding ETP, acenocoumarol affected thrombin generation more than dabigatran (area under the curve [AUC], P < .001), while statistically significant associations were detected between dabigatran levels, as determined by the HTI assay, and almost all parameters of ETP assay (AUC, P < .001). Conclusion: The role of ETP in estimating anticoagulant activity of dabigatran possibly requires further research. © The Author(s) 2014.en
dc.language.isoengen
dc.sourceClinical and Applied Thrombosis/Hemostasisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectPriority journalen
dc.subjectClinical articleen
dc.subjectDrug effecten
dc.subjectArea under the curveen
dc.subjectMaleen
dc.subjectArticleen
dc.subjectDrug blood levelen
dc.subjectAdrenalinen
dc.subjectAnticoagulationen
dc.subjectLaboratory testen
dc.subjectAcenocoumarolen
dc.subjectAnticoagulantsen
dc.subjectAntithrombinen
dc.subjectAntithrombinsen
dc.subjectAtrial fibrillationen
dc.subjectBlood analysis equipmenten
dc.subjectBlood clottingen
dc.subjectBlood clotting testen
dc.subjectBlood coagulationen
dc.subjectBlood coagulation testsen
dc.subjectCardiologyen
dc.subjectDabigatranen
dc.subjectDabigatran etexilateen
dc.subjectDevicesen
dc.subjectDrug effectsen
dc.subjectHemostasisen
dc.subjectLysisen
dc.subjectThrombinen
dc.subjectThrombin inhibitoren
dc.titleLaboratory Assessment of the Anticoagulant Activity of Dabigatranen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1177/1076029614564209
dc.description.volume21
dc.description.issue5
dc.description.startingpage434
dc.description.endingpage445
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBonovas, Stefanos [0000-0001-6102-6579]
dc.contributor.orcidKopterides, Petros [0000-0002-7682-4482]
dc.contributor.orcidKokoris, Styliani [0000-0002-1635-7309]
dc.contributor.orcidIkonomidis, Ignatios [0000-0001-8241-7886]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0001-6102-6579
dc.gnosis.orcid0000-0002-7682-4482
dc.gnosis.orcid0000-0002-1635-7309
dc.gnosis.orcid0000-0001-8241-7886


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