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dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorParaskeva, D.en
dc.contributor.authorHatzitheodorou, E.en
dc.contributor.authorMoschidis, Zissisen
dc.contributor.authorSypsa, V.en
dc.contributor.authorZavitsanos, X.en
dc.contributor.authorKalapothaki, Victoriaen
dc.contributor.authorHatzakis, A.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorParaskeva, D.en
dc.creatorHatzitheodorou, E.en
dc.creatorMoschidis, Zissisen
dc.creatorSypsa, V.en
dc.creatorZavitsanos, X.en
dc.creatorKalapothaki, Victoriaen
dc.creatorHatzakis, A.en
dc.description.abstractBackground. The effect of hepatitis B virus (HBV) infection on the natural history of human immunodeficiency virus (HIV) disease remains uncertain. Therefore, a retrospective cohort study was conducted to examine the influence of HIV-HBV coinfection on AIDS development and overall mortality. Moreover, our results were added to those of previous studies in a literature-based meta-analysis. Methods. Serum samples obtained from HIV-seropositive patients from 1984 through 2003 were retrospectively tested for hepatitis B surface antigen. Multivariable analyses were performed using Poisson and logistic regression models. For meta-analytic purposes, eligible articles were identified and relevant data were abstracted. Pooled estimates of effect were calculated applying fixed and random effects models. Results. The prevalence of chronic HBV infection (documented hepatitis B surface antigen seropositivity for >6 months) among 1729 HIV-positive patients was ∼6%. The multivariable analyses in our primary study revealed no significant impact of concomitant HIV-HBV infection on progression to AIDS and all-cause mortality. However, a meta-analysis performed on data from 12,382 patients enrolled in 11 studies revealed a significant effect of HIV- HBV coinfection on overall mortality (pooled effect estimate, 1.36; 95% confidence interval, 1.12-1.64). The increased rate of death among coinfected individuals was observed in the meta-analyses of studies conducted both before (pooled effect estimate, 1.60; 95% confidence interval, 1.07-2.39) and after (pooled effect estimate, 1.28; 95% confidence interval, 1.03-1.60) commencement of highly active antiretroviral therapy. Conclusions. HIV-HBV coinfection seems to affect all-cause mortality, and strategies to reduce liver damage in patients coinfected with HIV and HBV are justified. © 2009 by the Infectious Diseases Society of America. All rights reserved.en
dc.sourceClinical Infectious Diseasesen
dc.subjectControlled studyen
dc.subjectMajor clinical studyen
dc.subjectDisease progressionen
dc.subjectPriority journalen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectDisease courseen
dc.subjectBlood samplingen
dc.subjectCohort analysisen
dc.subjectLiver injuryen
dc.subjectHighly active antiretroviral therapyen
dc.subjectAcquired immunodeficiency syndromeen
dc.subjectHepatitis ben
dc.subjectCohort studiesen
dc.subjectAntiretrovirus agenten
dc.subjectHepatitis ben
dc.subjectHepatitis b virusen
dc.subjectHuman immunodeficiency virus infected patienten
dc.subjectMixed infectionen
dc.subjectAcquired immune deficiency syndromeen
dc.subjectHepatitis b surface antigenen
dc.subjectHepatitis b surface antigensen
dc.titleImpact of hepatitis B virus infection on the progression of AIDS and mortality in HIV-infected individuals: A cohort study and meta-analysisen
dc.description.endingpage1771Ιατρική Σχολή / Medical School
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]

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