Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B-cell lymphoma: A phase-II trial by the Hellenic Cooperative Oncology Group
dc.contributor.author | Papageorgiou, E. | en |
dc.contributor.author | Tsirigotis, P. | en |
dc.contributor.author | Dimopoulos, M. A. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Fountzilas, George | en |
dc.contributor.author | Papageorgiou, S. | en |
dc.contributor.author | Economopoulos, T. | en |
dc.creator | Papageorgiou, E. | en |
dc.creator | Tsirigotis, P. | en |
dc.creator | Dimopoulos, M. A. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Fountzilas, George | en |
dc.creator | Papageorgiou, S. | en |
dc.creator | Economopoulos, T. | en |
dc.date.accessioned | 2018-06-22T09:54:12Z | |
dc.date.available | 2018-06-22T09:54:12Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42235 | |
dc.description.abstract | To investigate the efficacy and toxicity of the combination of gemcitabine and vinorelbine in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBL), 22 patients with relapsed or refractory DLBL were treated with gemcitabine 1000 mg/m2 and vinorelbine 30 mg/m2 on days 1 and 8 every 3 wk for a maximum of six cycles. Fourteen patients were considered chemosensitive while eight patients were considered chemoresistant to the last treatment regimen. All 22 patients were assessed for response to treatment. Three patients (14%) achieved complete remission and eight patients (36%) had partial remission of their disease, with an overall response rate of 50%. With a median follow up of 44 months, the median time to progression (TTP) for all patients was 8.1 months while the median overall survival (OS) was 12.9 months. Toxicity was minimal and all patients were treated on an outpatient basis. The combination of gemcitabine and vinorelbine is an effective and well-tolerated regimen for patients with relapsed of refractory DLBL. © Blackwell Munksgaard 2005. | en |
dc.language.iso | eng | en |
dc.source | European journal of haematology | en |
dc.subject | Article | en |
dc.subject | Cisplatin | en |
dc.subject | Cyclophosphamide | en |
dc.subject | Cytarabine | en |
dc.subject | Etoposide | en |
dc.subject | Human | en |
dc.subject | Prednisone | en |
dc.subject | Vincristine | en |
dc.subject | 80 and over | en |
dc.subject | Aged | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Controlled study | en |
dc.subject | Female | en |
dc.subject | Middle aged | en |
dc.subject | Cancer combination chemotherapy | en |
dc.subject | Cancer growth | en |
dc.subject | Cancer survival | en |
dc.subject | Follow up | en |
dc.subject | Priority journal | en |
dc.subject | Alopecia | en |
dc.subject | Anemia | en |
dc.subject | Antineoplastic combined chemotherapy protocols | en |
dc.subject | Bone marrow suppression | en |
dc.subject | Clinical article | en |
dc.subject | Clinical trial | en |
dc.subject | Controlled clinical trial | en |
dc.subject | Drug efficacy | en |
dc.subject | Febrile neutropenia | en |
dc.subject | Leukopenia | en |
dc.subject | Methylprednisolone | en |
dc.subject | Mucosa inflammation | en |
dc.subject | Multicenter study | en |
dc.subject | Navelbine | en |
dc.subject | Neurotoxicity | en |
dc.subject | Neutropenia | en |
dc.subject | Phase 2 clinical trial | en |
dc.subject | Stomatitis | en |
dc.subject | Thrombocytopenia | en |
dc.subject | Vinblastine | en |
dc.subject | Vinorelbine | en |
dc.subject | Salvage therapy | en |
dc.subject | Survival analysis | en |
dc.subject | Fever | en |
dc.subject | Granulocyte colony stimulating factor | en |
dc.subject | Treatment outcome | en |
dc.subject | Cancer relapse | en |
dc.subject | Relapse | en |
dc.subject | B cell lymphoma | en |
dc.subject | Epirubicin | en |
dc.subject | Male | en |
dc.subject | B-cell | en |
dc.subject | Diffuse | en |
dc.subject | Large cell lymphoma | en |
dc.subject | Large-cell | en |
dc.subject | Lymphoma | en |
dc.subject | Side effect | en |
dc.subject | Vomiting | en |
dc.subject | Nausea | en |
dc.subject | Ifosfamide | en |
dc.subject | Deoxycytidine | en |
dc.subject | Gemcitabine | en |
dc.subject | Cancer regression | en |
dc.subject | Remission induction | en |
dc.subject | Chemosensitivity | en |
dc.subject | Mitoguazone | en |
dc.subject | Refractory | en |
dc.title | Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B-cell lymphoma: A phase-II trial by the Hellenic Cooperative Oncology Group | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1111/j.1600-0609.2005.00482.x | |
dc.description.volume | 75 | |
dc.description.issue | 2 | |
dc.description.startingpage | 124 | |
dc.description.endingpage | 129 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 |
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