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dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorFizazi, K.en
dc.creatorPavlidis, Nicholasen
dc.creatorFizazi, K.en
dc.date.accessioned2018-06-22T09:54:15Z
dc.date.available2018-06-22T09:54:15Z
dc.date.issued2005
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42268
dc.description.abstractCarcinoma of unknown primary (CUP) is one of the 10 most frequent cancers worldwide. It constitutes 3-5% of all human malignancies. Patients with CUP present with metastases without an established primary site. CUP manifests as an heterogenous group of mainly epithelial cancers recognised by distinct clinicopathological entities. The diagnostic work-up includes extensive histopathology investigations and modern imaging technology. Nevertheless, the primary tumour remains undetected most of the time. Certain clinicopathological CUP entities are considered as favourable subsets responding to systemic platinum-based chemotherapy or managed by locoregional treatment. These subsets are: the poorly differentiated carcinomas involving the mediastinal- retroperitoneal nodes, peritoneal papillary serous adenocarcinomatosis in females, poorly differentiated neuroendocrine carcinomas, isolated axillary node adenocarcinomas in females or cervical nodal involvement by a squamous cell carcinoma. Patients who belong to the non-favourable subsets have a worse prognosis. © 2005 Published by Elsevier Ireland Ltd.en
dc.language.isoengen
dc.sourceCritical reviews in oncology/hematologyen
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectCancer chemotherapyen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectCarboplatinen
dc.subjectFollow upen
dc.subjectPaclitaxelen
dc.subjectPlatinum derivativeen
dc.subjectGemcitabineen
dc.subjectTaxane derivativeen
dc.subjectPrognosisen
dc.subjectCancer stagingen
dc.subjectTreatment outcomeen
dc.subjectReviewen
dc.subjectCancer surgeryen
dc.subjectNeoplasm metastasisen
dc.subjectCancer diagnosisen
dc.subjectCancer mortalityen
dc.subjectCancer radiotherapyen
dc.subjectIrinotecanen
dc.subjectAxillary lymph nodeen
dc.subjectCancer incidenceen
dc.subjectCanceren
dc.subjectAdenocarcinomaen
dc.subjectParaaortic lymph nodeen
dc.subjectSquamous cell carcinomaen
dc.subjectCancer localizationen
dc.subjectEndoscopyen
dc.subjectCervical lymph nodeen
dc.subjectChromosomal instabilityen
dc.subjectChromosome aberrationen
dc.subjectCancer epidemiologyen
dc.subjectDiagnostic procedureen
dc.subjectCarcinoma of unknown primaryen
dc.subjectImmunophenotypingen
dc.subjectTumouren
dc.titleCancer of unknown primary (CUP)en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.critrevonc.2004.10.002
dc.description.volume54
dc.description.issue3
dc.description.startingpage243
dc.description.endingpage250
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.gnosis.orcid0000-0002-2195-9961


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