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dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorBai, M. C.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorAgnantis, Niki J.en
dc.creatorPavlidis, Nicholasen
dc.creatorBriassoulis, E. Chen
dc.creatorBai, M. C.en
dc.creatorFountzilas, Georgeen
dc.creatorAgnantis, Niki J.en
dc.date.accessioned2018-06-22T09:54:17Z
dc.date.available2018-06-22T09:54:17Z
dc.date.issued1995
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42284
dc.description.abstractThe role of oncogenes in carcinoma of unknown primary site (CUP) has not yet been elucidated. In the present study the expression of the c-myc p62, ras p21 and c-erb B p185 oncoproteins were studied by a 3-step immunoperoxidase technique in 26 cases of CUP. Positive immunoreactivity was observed in 96% of the cases for c-myc, 92% for ras and in 65% for c-erb-2, with at least half of tumor cells labelled in 85%, 92% and 58% respectively. The degree of staining intensity was considered moderate or strong in more than half of the cases for all oncogene products. In conclusion, our results showed that patients with CUP have an extremely high overexpression of all three oncogenes studied. Nevertheless, the biological role of these overexpressed oncoproteins, their relationship with different histological or clinical parameters and their diagnostic or prognostic value need further evaluation.en
dc.language.isoengen
dc.sourceAnticancer Researchen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectNeoplasmsen
dc.subjectAdenocarcinomaen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMiddle ageden
dc.subjectPriority journalen
dc.subjectClinical articleen
dc.subjectNeoplasticen
dc.subjectCarcinomaen
dc.subjectMaleen
dc.subjectGene expression regulationen
dc.subjectUnclassified drugen
dc.subjectTumor cellen
dc.subjectOncogeneen
dc.subjectSquamous cellen
dc.subjectUnknown primaryen
dc.subjectCarcinomaen
dc.subjectOncoproteinen
dc.subjectHuman cellen
dc.subjectImmunoreactivityen
dc.subjectOncogene c erben
dc.subjectOncogene c mycen
dc.subjectOncogene rasen
dc.subjectGene expressionen
dc.subjectNeoplasm proteinsen
dc.subjectErbb-2en
dc.subjectReceptoren
dc.subjectProtein p21en
dc.subjectImmunoenzyme techniquesen
dc.subjectProto-oncogene proteins p21(ras)en
dc.subjectC-erbb-2en
dc.subjectC-mycen
dc.subjectCarcinoma of unknown primaryen
dc.subjectOncogenesen
dc.subjectProtein p185en
dc.subjectProtein p62en
dc.subjectProto-oncogene proteins c-mycen
dc.subjectRasen
dc.titleOverexpression of C-myc, ras and C-erb B-2 oncoproteins in carcinoma of unknown primary originen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume15
dc.description.issue6 Ben
dc.description.startingpage2563
dc.description.endingpage2567
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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