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dc.contributor.authorPentheroudakis, Georgeen
dc.contributor.authorBatistatou, Annaen
dc.contributor.authorKalogeras, K. T.en
dc.contributor.authorKronenwett, R.en
dc.contributor.authorWirtz, R. M.en
dc.contributor.authorBournakis, E.en
dc.contributor.authorEleftheraki, A. G.en
dc.contributor.authorPectasides, Dimitriosen
dc.contributor.authorBobos, M.en
dc.contributor.authorPapaspirou, I.en
dc.contributor.authorKamina, S.en
dc.contributor.authorGogas, H.en
dc.contributor.authorKoutras, A. K.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorFountzilas, Georgeen
dc.creatorPentheroudakis, Georgeen
dc.creatorBatistatou, Annaen
dc.creatorKalogeras, K. T.en
dc.creatorKronenwett, R.en
dc.creatorWirtz, R. M.en
dc.creatorBournakis, E.en
dc.creatorEleftheraki, A. G.en
dc.creatorPectasides, Dimitriosen
dc.creatorBobos, M.en
dc.creatorPapaspirou, I.en
dc.creatorKamina, S.en
dc.creatorGogas, H.en
dc.creatorKoutras, A. K.en
dc.creatorPavlidis, Nicholasen
dc.creatorFountzilas, Georgeen
dc.date.accessioned2018-06-22T09:54:24Z
dc.date.available2018-06-22T09:54:24Z
dc.date.issued2011
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42338
dc.description.abstractWe evaluated the prognostic and predictive utility of β-tubulin isotype III (TUBB3) tumour gene transcription in early breast cancer patients enrolled in a randomised study. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was applied for assessment of TUBB3, ER, PgR, HER2 and MAPT messenger RNA and immunohistochemistry (IHC) for protein expression in 314 patients enrolled in trial HE10/97, evaluating epirubicin-alkylator adjuvant chemotherapy with or without paclitaxel. High TUBB3 mRNA status was associated with advanced T stage, high histological grade, low mRNA and protein levels of ER, PgR and MAPT, and high levels of HER2 (p < 0.001). At a median follow-up of 98 months, multivariate analysis showed high TUBB3 mRNA status to have prognostic significance for DFS (HR = 1.83, 95% CI 1.25-2.68, p = 0.002) and OS (HR = 1.71, 95% CI 1.03-2.83, p = 0.038), along with the number of involved axillary nodes, PgR mRNA status and tumour grade. TUBB3 mRNA levels did not predict benefit from inclusion of paclitaxel in adjuvant chemotherapy (test for interaction p = 0.96 for OS, p = 0.46 for DFS). Transcriptional activity of β-tubulin isotype III in early breast cancer is an adverse prognostic factor, though not a predictive one for taxane efficacy. © 2011 Springer Science+Business Media, LLC.en
dc.language.isoengen
dc.sourceBreast cancer research and treatmenten
dc.subjectΒ-tubulin isotype iiiel
dc.subjectArticleen
dc.subjectYoung adulten
dc.subjectCyclophosphamideen
dc.subjectFluorouracilen
dc.subjectHumanen
dc.subjectMethotrexateen
dc.subjectTamoxifenen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast neoplasmsen
dc.subjectCancer patienten
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectMiddle ageden
dc.subjectFollow upen
dc.subjectNeoplasm stagingen
dc.subjectPaclitaxelen
dc.subjectPredictive value of testsen
dc.subjectPriority journalen
dc.subjectPrognosisen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectDrug efficacyen
dc.subjectHuman tissueen
dc.subjectSurvival analysisen
dc.subjectCancer stagingen
dc.subjectDisease free survivalen
dc.subjectGranulocyte colony stimulating factoren
dc.subjectNeoplasticen
dc.subjectOverall survivalen
dc.subjectOutcome assessmenten
dc.subjectEpirubicinen
dc.subjectImmunohistochemistryen
dc.subjectProtein analysisen
dc.subjectProtein expressionen
dc.subjectGene expression regulationen
dc.subjectUnclassified drugen
dc.subjectAxillary lymph nodeen
dc.subjectBreast canceren
dc.subjectCancer gradingen
dc.subjectEstrogen receptoren
dc.subjectHistopathologyen
dc.subjectMastectomyen
dc.subjectProgesterone receptoren
dc.subjectAdjuvant chemotherapyen
dc.subjectMultiple cycle treatmenten
dc.subjectGene expressionen
dc.subjectRnaen
dc.subjectGenetic transcriptionen
dc.subjectTranslational researchen
dc.subjectMultivariate analysisen
dc.subjectMessenger rnaen
dc.subjectReverse transcription polymerase chain reactionen
dc.subjectEpidermal growth factor receptor 2en
dc.subjectEarly canceren
dc.subjectPartial mastectomyen
dc.subjectCancer tissueen
dc.subjectMessengeren
dc.subjectPredictive valueen
dc.subjectExcision repair cross complementing protein 1en
dc.subjectBeta tubulinen
dc.subjectBeta tubulin iiien
dc.subjectBeta tubulin iii geneen
dc.subjectGene expression profilingen
dc.subjectPrognostic/predictive factorsen
dc.subjectTau proteinen
dc.subjectTubulinen
dc.subjectTumor geneen
dc.titlePrognostic utility of β-tubulin isotype III and correlations with other molecular and clinicopathological variables in patients with early breast cancer: A translational Hellenic Cooperative Oncology Group (HeCOG) studyen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s10549-011-1427-0
dc.description.volume127
dc.description.issue1
dc.description.startingpage179
dc.description.endingpage193
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidPentheroudakis, George [0000-0002-6632-2462]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-6632-2462


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