• Article  
  
  

  Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment 

  Martin, John D.; Panagi, Myrofora; Wang, Chenyu; Khan, Thahomina T.; Martin, Margaret R.; Voutouri, Chrysovalantis; Toh, Kazuko; Papageorgis, Panagiotis; Mpekris, Fotios; Polydorou, Christiana; Ishii, Genichiro; Takahashi, Shinichiro; Gotohda, Naoto; Suzuki, Toshiyuki; Wilhelm, Matthew E.; Melo, Vinicio Alejandro; Quader, Sabina; Norimatsu, Jumpei; Lanning, Ryan M.; Kojima, Motohiro; Stuber, Matthew David; Stylianopoulos, Triantafyllos; Kataoka, Kazunori; Cabral, Horacio (2019)

  Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we ...

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• Article  
  
  

  Activin A Signaling Regulates IL13Rα2 Expression to Promote Breast Cancer Metastasis 

  Kalli, Maria; Mpekris, Fotios; Wong, Chen K.; Panagi, Myrofora; Ozturk, Sait; Thiagalingam, Sam; Stylianopoulos, Triantafyllos; Papageorgis, Panagiotis (2019)

  Metastatic dissemination of cancer cells to distal organs is the major cause of death for patients suffering from the aggressive basal-like breast cancer (BLBC) subtype. Recently, we have shown that interleukin 13 receptor ...

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• Conference Object  
  
  

  Deployment and Reconfiguration Approach of Linkage Structures 

  Dimitriou, P.; Phocas, Marios C.; Kontovourkis, Odysseas; Matheou, M.; Christoforou, Eftychios G. (Ryerson University, 2019)

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  Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma 

  Zhao, Yanxia; Cao, Jinghong; Melamed, Alexander; Worley, Michael; Gockley, Allison; Jones, Dennis; Nia, Hadi T.; Zhang, Yanling; Stylianopoulos, Triantafyllos; Kumar, Ashwin S.; Mpekris, Fotios; Datta, Meenal; Sun, Yao; Wu, Limeng; Gao, Xing; Yeku, Oladapo; Del Carmen, Marcela G.; Spriggs, David R.; Jain, Rakesh K.; Xu, Lei (2019)

  In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to enhance drug delivery and therapeutic efficacy by remodeling the ...

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• Article  
  
  

  Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts 

  Stylianou, Andreas; Gkretsi, Vasiliki; Louca, Maria; Zacharia, Lefteris C.; Stylianopoulos, Triantafyllos (2019)

  In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as collagen, by stromal cells, mainly ...

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• Article  
  
  

  Correction: In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability 

  Vavourakis, Vasileios; Stylianopoulos, Triantafyllos; Wijeratne, Peter A. (2019)

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• Article  
  
  

  Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression 

  Kalli, Maria; Voutouri, Chrysovalantis; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)

  Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer patients representing a negative prognostic factor. Indeed, it is of ...

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• Article  
  
  

  Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies 

  Voutouri, Chrysovalantis; Kirkpatrick, Nathaniel D.; Chung, Euiheon; Mpekris, Fotios; Baish, James W.; Munn, Lance L.; Fukumura, Dai; Stylianopoulos, Triantafyllos; Jain, Rakesh K. (2019)

  Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can ...

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• Article  
  
  

  Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion 

  Louca, Maria; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)

  Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor due to its invasive phenotype. Ras suppressor 1 (RSU-1) is a cell-extracellular matrix adhesion protein and we recently found that it promotes cell ...

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• Article  
  
  

  Editorial: Metastasis: From Cell Adhesion and Beyond 

  Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)

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• Article  
  
  

  A simplified approach for the determination of fitting constants in Oliver-Pharr method regarding biological samples 

  Kontomaris, S. V.; Stylianou, A.; Nikita, K. S.; Malamou, A.; Stylianopoulos, Triantafyllos (2019)

  The atomic force microscopy (AFM) nanoindentation regarding biological samples is a challenging procedure. Biological samples at the nanoscale can be considered as purely elastic materials under the condition that the ...

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• Article  
  
  

  On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas 

  Mascheroni, Pietro; López Alfonso, Juan Carlos; Kalli, Maria; Stylianopoulos, Triantafyllos; Meyer-Hermann, Michael; Hatzikirou, Haralampos (2019)

  Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, ...

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• Article  
  
  

  Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness 

  Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos (2018)

  Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major ...

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• Article  
  
  

  Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI 

  Angeli, Stelios; Emblem, Kyrre E.; Due-Tonnessen, Paulina; Stylianopoulos, Triantafyllos (2018)

  Previous studies to simulate brain tumor progression, often investigate either temporal changes in cancer cell density or the overall tissue-level growth of the tumor mass. Here, we developed a computational model to bridge ...

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• Article  
  
  

  Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells 

  Kalli, Maria; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)

  Solid stress is a biomechanical abnormality of the tumor microenvironment that plays a crucial role in tumor progression. When it is applied to cancer cells, solid stress hinders their proliferation rate and promotes cancer ...

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• Article  
  
  

  Atomic force microscopy nano-characterization of 3D collagen gels with tunable stiffness 

  Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)

  As extracellular matrix (ECM) nano-characteristics play a crucial role in cell behavior, including cancer development and metastasis, several ECM in vitro models have been used in order to study cells behavior under different ...

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• Article  
  
  

  Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform 

  Gkretsi, Vasiliki; Kalli, Maria; Efstathiades, Christodoulos; Papageorgis, Panagiotis; Papanikolaou, Vassilios; Zacharia, Lefteris C.; Tsezou, Aspasia; Athanassiou, Evangelos; Stylianopoulos, Triantafyllos (2019)

  Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin ...

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• Article  
  
  

  Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation 

  Louca, Maria; Stylianou, Andreas; Minia, Angeliki; Pliaka, Vaia; Alexopoulos, Leonidas G.; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)

  Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) ...

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• Article  
  
  

  Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy 

  Stylianopoulos, Triantafyllos; Munn, Lance L.; Jain, Rakesh K. (2018)

  A solid tumor is like an aberrant organ - comprised of cancer cells and a variety of host cells embedded in an extracellular matrix - nourished by blood vessels and drained by lymphatic vessels. In its journey from the ...

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• Article  
  
  

  A quantitative in silico platform for simulating cytotoxic and nanoparticle drug delivery to solid tumours 

  Wijeratne, Peter A.; Vavourakis, Vasileios (2019)

  The role of tumour–host mechano-biology and the mechanisms involved in the delivery of anti-cancer drugs have been extensively studied using in vitro and in vivo models. A complementary approach is offered by in silico ...

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