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Fabrication of nanorods by metal evaporation inside the pores of ultra-thin porous alumina templates
(2007)
Porous alumina has attracted a great deal of attention as a template material for the growth of nanowires and nanodots. Typically, the pores have a high aspect ratio, which forbids the use of evaporation techniques for ...
Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
(2009)
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...
Broom-like and flower-like heterostructures of silver molybdate through pH controlled self assembly
(2012)
Silver molybdate microrods are selfassembled into micron sized, broom-like and flowerlike structures. Our investigations indicate that through a simple hydrothermal process, large scale production of such structure is ...
Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPA)
(2017)
A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus ...
Experimental methods for flow and aerosol measurements in human airways and their replicas
(2018)
Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant ...
Spectroscopic evidence for a pseudogap in the normal state of underdoped high-T(c) superconductors
(1996)
It is well known that BCS mean-field theory is remarkably successful in describing conventional superconductors. A central concept of BCS theory is the energy gap in the electronic excitation spectrum below the superconducting ...
Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy
(2017)
Targeting the rich extracellular matrix of desmoplastic tumors has been successfully shown to normalize collagen and hyaluronan levels and re-engineer intratumoral mechanical forces, improving tumor perfusion and chemotherapy. ...
Role of vascular normalization in benefit from metronomic chemotherapy
(2017)
Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in ...
Multiscale modelling of solid tumour growth: the effect of collagen micromechanics
(2016)
Here we introduce a model of solid tumour growth coupled with a multiscale biomechanical description of the tumour microenvironment, which facilitates the explicit simulation of fibre–fibre and tumour–fibre interactions. ...
Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...