Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Jain, Rakesh K."
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Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies
Voutouri, Chrysovalantis; Kirkpatrick, Nathaniel D.; Chung, Euiheon; Mpekris, Fotios; Baish, James W.; Munn, Lance L.; Fukumura, Dai; Stylianopoulos, Triantafyllos; Jain, Rakesh K. (2019)Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can ...
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Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
Zhao, Yanxia; Cao, Jinghong; Melamed, Alexander; Worley, Michael; Gockley, Allison; Jones, Dennis; Nia, Hadi T.; Zhang, Yanling; Stylianopoulos, Triantafyllos; Kumar, Ashwin S.; Mpekris, Fotios; Datta, Meenal; Sun, Yao; Wu, Limeng; Gao, Xing; Yeku, Oladapo; Del Carmen, Marcela G.; Spriggs, David R.; Jain, Rakesh K.; Xu, Lei (2019)In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to enhance drug delivery and therapeutic efficacy by remodeling the ...
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Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside
Stylianopoulos, Triantafyllos; Munn, Lance L.; Jain, Rakesh K. (2018)Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology has provided powerful insights into the mechanisms by which these ...
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Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy
Stylianopoulos, Triantafyllos; Munn, Lance L.; Jain, Rakesh K. (2018)A solid tumor is like an aberrant organ - comprised of cancer cells and a variety of host cells embedded in an extracellular matrix - nourished by blood vessels and drained by lymphatic vessels. In its journey from the ...