Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Stylianopoulos, Triantafyllos"
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Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness
Voutouri, Chrysovalantis; Stylianopoulos, Triantafyllos (2018)Hyaluronan is abundant in the extracellular matrix of many desmoplastic tumors and determines in large part the tumor biochemical and mechanical microenvironment. Additionally, it has been identified as one of the major ...
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Activin A Signaling Regulates IL13Rα2 Expression to Promote Breast Cancer Metastasis
Kalli, Maria; Mpekris, Fotios; Wong, Chen K.; Panagi, Myrofora; Ozturk, Sait; Thiagalingam, Sam; Stylianopoulos, Triantafyllos; Papageorgis, Panagiotis (2019)Metastatic dissemination of cancer cells to distal organs is the major cause of death for patients suffering from the aggressive basal-like breast cancer (BLBC) subtype. Recently, we have shown that interleukin 13 receptor ...
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AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level
Stylianou, Andreas; Lekka, Malgorzata; Stylianopoulos, Triantafyllos (2018)Cancer development and progression are closely associated with changes both in the mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix (ECM) structure, composition, and mechanics. In this ...
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Atomic force microscopy nano-characterization of 3D collagen gels with tunable stiffness
Stylianou, Andreas; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)As extracellular matrix (ECM) nano-characteristics play a crucial role in cell behavior, including cancer development and metastasis, several ECM in vitro models have been used in order to study cells behavior under different ...
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Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis
Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts
Stylianou, Andreas; Gkretsi, Vasiliki; Louca, Maria; Zacharia, Lefteris C.; Stylianopoulos, Triantafyllos (2019)In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as collagen, by stromal cells, mainly ...
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Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion
Louca, Maria; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor due to its invasive phenotype. Ras suppressor 1 (RSU-1) is a cell-extracellular matrix adhesion protein and we recently found that it promotes cell ...
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Correction: In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Vavourakis, Vasileios; Stylianopoulos, Triantafyllos; Wijeratne, Peter A. (2019)
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Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis
Kalli, Maria; Stylianopoulos, Triantafyllos (2018)Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...
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Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform
Gkretsi, Vasiliki; Kalli, Maria; Efstathiades, Christodoulos; Papageorgis, Panagiotis; Papanikolaou, Vassilios; Zacharia, Lefteris C.; Tsezou, Aspasia; Athanassiou, Evangelos; Stylianopoulos, Triantafyllos (2019)Extracellular matrix (ECM)-adhesion proteins and actin cytoskeleton are pivotal in cancer cell invasion. Ras Suppressor-1 (RSU-1), a cell-ECM adhesion protein that interacts with PINCH-1, thus being connected to Integrin ...
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Dexamethasone Increases Cisplatin-Loaded Nanocarrier Delivery and Efficacy in Metastatic Breast Cancer by Normalizing the Tumor Microenvironment
Martin, John D.; Panagi, Myrofora; Wang, Chenyu; Khan, Thahomina T.; Martin, Margaret R.; Voutouri, Chrysovalantis; Toh, Kazuko; Papageorgis, Panagiotis; Mpekris, Fotios; Polydorou, Christiana; Ishii, Genichiro; Takahashi, Shinichiro; Gotohda, Naoto; Suzuki, Toshiyuki; Wilhelm, Matthew E.; Melo, Vinicio Alejandro; Quader, Sabina; Norimatsu, Jumpei; Lanning, Ryan M.; Kojima, Motohiro; Stuber, Matthew David; Stylianopoulos, Triantafyllos; Kataoka, Kazunori; Cabral, Horacio (2019)Dexamethasone is a glucocorticoid steroid with anti-inflammatory properties used to treat many diseases, including cancer, in which it helps manage various side effects of chemo-, radio-, and immunotherapies. Here, we ...
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A discussion regarding the approximation of cylindrical and spherical shaped samples as half spaces in AFM nanoindentation experiments
Kontomaris, Stylianos-Vasileios; Stylianou, Andreas; Malamou, Anna; Stylianopoulos, Triantafyllos (2018)A common assumption of nanoidentation experiments is to consider the sample as an elastic half space due to the simplicity of the analysis regarding the Young’s modulus calculation. However, in the nano—dimensions a sample ...
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Editorial: Metastasis: From Cell Adhesion and Beyond
Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)
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Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies
Voutouri, Chrysovalantis; Kirkpatrick, Nathaniel D.; Chung, Euiheon; Mpekris, Fotios; Baish, James W.; Munn, Lance L.; Fukumura, Dai; Stylianopoulos, Triantafyllos; Jain, Rakesh K. (2019)Cooption of the host vasculature is a strategy that some cancers use to sustain tumor progression without—or before—angiogenesis or in response to antiangiogenic therapy. Facilitated by certain growth factors, cooption can ...
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In-silico dynamic analysis of cytotoxic drug administration to solid tumours: Effect of binding affinity and vessel permeability
Vavourakis, Vasileios; Stylianopoulos, Triantafyllos; Wijeratne, Peter A. (2018)The delivery of blood-borne therapeutic agents to solid tumours depends on a broad range of biophysical factors. We present a novel multiscale, multiphysics, in-silico modelling framework that encompasses dynamic tumour ...
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Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma
Zhao, Yanxia; Cao, Jinghong; Melamed, Alexander; Worley, Michael; Gockley, Allison; Jones, Dennis; Nia, Hadi T.; Zhang, Yanling; Stylianopoulos, Triantafyllos; Kumar, Ashwin S.; Mpekris, Fotios; Datta, Meenal; Sun, Yao; Wu, Limeng; Gao, Xing; Yeku, Oladapo; Del Carmen, Marcela G.; Spriggs, David R.; Jain, Rakesh K.; Xu, Lei (2019)In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have been shown to inversely correlate with survival. We sought to enhance drug delivery and therapeutic efficacy by remodeling the ...
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Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression
Kalli, Maria; Voutouri, Chrysovalantis; Minia, Angeliki; Pliaka, Vaia; Fotis, Christos; Alexopoulos, Leonidas G.; Stylianopoulos, Triantafyllos (2019)Mechanical compression is a common abnormality of brain tumors that has been shown to be responsible for the severe neurological defects of brain cancer patients representing a negative prognostic factor. Indeed, it is of ...
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NAA40 contributes to colorectal cancer growth by controlling PRMT5 expression
Demetriadou, Christina; Pavlou, Demetria; Mpekris, Fotios; Achilleos, Charis; Stylianopoulos, Triantafyllos; Zaravinos, Apostolos; Papageorgis, Panagiotis; Kirmizis, Antonis (2019)N-alpha-acetyltransferase 40 (NAA40) catalyzes the transfer of an acetyl moiety to the alpha-amino group of serine 1 (S1) on histones H4 and H2A. Our previous studies linked NAA40 and its corresponding N-terminal acetylation ...
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On the Impact of Chemo-Mechanically Induced Phenotypic Transitions in Gliomas
Mascheroni, Pietro; López Alfonso, Juan Carlos; Kalli, Maria; Stylianopoulos, Triantafyllos; Meyer-Hermann, Michael; Hatzikirou, Haralampos (2019)Tumor microenvironment is a critical player in glioma progression, and novel therapies for its targeting have been recently proposed. In particular, stress-alleviation strategies act on the tumor by reducing its stiffness, ...
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Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation
Louca, Maria; Stylianou, Andreas; Minia, Angeliki; Pliaka, Vaia; Alexopoulos, Leonidas G.; Gkretsi, Vasiliki; Stylianopoulos, Triantafyllos (2019)Most gliomas are invasive tumors formed from glial cells and associated with high mortality rates. In this study, we characterized four glioma cell lines of varying degree of aggressiveness (H4, SW1088, A172 and U87-MG) ...