Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Sznitman, Josué"
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Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery
Koullapis, Pantelis; Ollson, Bo; Kassinos, Stavros C.; Sznitman, Josué (2019)Inhalation therapy is a hallmark of modern respiratory medicine. Over recent years, computational fluid-particle dynamics (CFPD) simulations of respiratory airflows and aerosol deposition in the lungs have rapidly developed ...
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Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
Ostrovski, Yan; Dorfman, Simon; Mezhericher, Maksim; Kassinos, Stavros; Sznitman, Josué (2019)The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the ...
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Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)
Das, Prashant; Nof, Eliram; Amirav, Israel; Kassinos, Stavros C.; Sznitman, Josué (2018)Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for maximal efficacy remains adversely low. By and ...
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Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations
Shachar-Berman, Lihi; Ostrovski, Yan; Koshiyama, Kenichiro; Wada, Shigeo; Kassinos, Stavros C.; Sznitman, Josué (2019)Non-spherical particles, and fibers in particular, are potentially attractive airborne carriers for pulmonary drug delivery. Not only do they exhibit a high surface-to-volume ratio relative to spherical aerosols, but their ...
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Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
Shachar-Berman, Lihi; Ostrovski, Yan; De Rosis, Alessandro; Kassinos, Stavros; Sznitman, Josué (2018)It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their ...