Browsing Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering by Author "Fukumura, D."
Now showing items 1-11 of 11
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Article
Benefits of vascular normalization are dose and time dependent - Letter
Huang, Y.; Stylianopoulos, T.; Duda, D. G.; Fukumura, D.; Jain, R. K. (2013)
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Article
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (2013)Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
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Conference Object
Design rules for cancer nanomedicines
Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...
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Article
Diffusion of particles in the extracellular matrix: The effect of repulsive electrostatic interactions
Stylianopoulos, T.; Poh, M. Z.; Insin, N.; Bawendi, M. G.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2010)Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that ...
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Conference Object
In vivo imaging of microvasculature using optical coherence tomography
Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (Correspondence Address: Vakoc, B. J., 2010)In vivo imaging technologies drive the development of improved cancer therapies by revealing critical aspects of the complex pathophysiology of solid tumors in small animal models[1]. The abnormal vascular function, which ...
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Article
Multistage nanoparticle delivery system for deep penetration into tumor tissue
Wong, C.; Stylianopoulos, T.; Cui, J.; Martin, J.; Chauhan, V. P.; Jiang, W.; Popovic, Z.; Jain, R. K.; Bawendi, M. G.; Fukumura, D. (2011)Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
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Article
Multistage nanoparticles for improved delivery into tumor tissue
Stylianopoulos, T.; Wong, C.; Bawendi, M. G.; Jain, R. K.; Fukumura, D. (2012)The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
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Article
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
Chauhan, V. P.; Stylianopoulos, T.; Martin, J. D.; PopoviÄ, Z.; Chen, O.; Kamoun, W. S.; Bawendi, M. G.; Fukumura, D.; Jain, R. K. (2012)The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
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Article
Scaling rules for diffusive drug delivery in tumor and normal tissues
Baish, J. W.; Stylianopoulos, T.; Lanning, R. M.; Kamoun, W. S.; Fukumura, D.; Munn, L. L.; Jain, R. K. (2011)Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
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Article
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
Vakoc, B. J.; Lanning, R. M.; Tyrrell, J. A.; Padera, T. P.; Bartlett, L. A.; Stylianopoulos, T.; Munn, L. L.; Tearney, G. J.; Fukumura, D.; Jain, R. K.; Bouma, Brett E. (2009)Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...
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Article
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...