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Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
(2009)
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...
Image-based multiscale modeling of collagen tissue-equivalents: Comparison of predicted fiber mechanics with polarimetric imaging
(Affiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Sander, E. A.Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2009)
Multiscale computation for bioartificial soft tissues with complex geometries
(2009)
The mechanical function of soft collagenous tissues is inherently multiscale, with the tissue dimension being in the centimeter length scale and the underlying collagen network being in the micrometer length scale. This ...
Image-based multiscale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels
(2009)
The mechanical environment plays an important role in cell signaling and tissue homeostasis. Unraveling connections between externally applied loads and the cellular response is often confounded by extracellular matrix ...
Permeability calculations in three-dimensional fiber networks
(Affiliation: Department of Chemical Engineering, University of Minnesota, United StatesAffiliation: Scientific Computation Research Center (SCOREC), RPIAffiliation: Department of Biomedical Engineering, University of Minnesota, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of MinnesotaUnited States, 2009)
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
(2009)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...