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The Solid Mechanics of Cancer and Strategies for Improved Therapy
(2017)
Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
Design of ball-milling experiments on Bi2Te3 thermoelectric material
(2013)
In this work, factorial ball-milling experiments have been applied to Bi2Te3 material, for the first time, aiming to investigate the effect of the main process parameters on the structural features and thermoelectric ...
Biphasic modeling of brain tumor biomechanics and response to radiation treatment
(2016)
Biomechanical forces are central in tumor progression and response to treatment. This becomes more important in brain cancers where tumors are surrounded by tissues with different mechanical properties. Existing mathematical ...
Mechanical stress regulates tissue oxygenation, cancer cell proliferation and drug delivery during progression of solid tumors
(Springer Verlag, 2016)
Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
A Frequency-Based Interpretation of Energy-Based Model Reduction of Linear Systems
(2016)
Various modeling techniques have been proposed in order to make modeling a more systematic procedure and to facilitate the development of modeling software that provide users, even experienced users, more ease when developing ...
Energy-based model reduction methodology for automated modeling
(2010)
In recent years, algorithms have been developed to help automate the production of dynamic system models. Part of this effort has been the development of algorithms that use modeling metrics for generating minimum complexity ...
Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation, and drug delivery
(2015)
Oxygen supply plays a central role in cancer cell proliferation. While vascular density increases at the early stages of carcinogenesis, mechanical solid stresses developed during growth compress tumor blood vessels and, ...
Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors
(2015)
Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)
Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
Design rules for cancer nanomedicines
(Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)
The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...