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Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
Scaling rules for diffusive drug delivery in tumor and normal tissues
(2011)
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
(2012)
The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)
Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
Multistage nanoparticles for improved delivery into tumor tissue
(2012)
The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
(2009)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...