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Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
(2009)
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
(2009)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...