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Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods
(2018)
Regional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung ...
An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung
(2018)
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to ...
Experimental methods for flow and aerosol measurements in human airways and their replicas
(2018)
Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant ...
Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery
(2019)
Inhalation therapy is a hallmark of modern respiratory medicine. Over recent years, computational fluid-particle dynamics (CFPD) simulations of respiratory airflows and aerosol deposition in the lungs have rapidly developed ...
PIV measurements of the SimInhale benchmark case
(2019)
Particle Image Velocimetry (PIV) measurements with the aim of providing experimental data for the SimInhale benchmark case are presented within this work. We, therefore, present a refractive index matched, transparent model ...
Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations
(2019)
Non-spherical particles, and fibers in particular, are potentially attractive airborne carriers for pulmonary drug delivery. Not only do they exhibit a high surface-to-volume ratio relative to spherical aerosols, but their ...
In silico assessment of mouth-throat effects on regional deposition in the upper tracheobronchial airways
(2018)
Regional deposition of inhaled medicines is a valuable metric of effectiveness in drug delivery applications to the lung. In silico methods are now emerging as a valuable tool for the detailed description of localized ...
Phase lock-on in periodically excited Bingham flow past a confined cylinder
(2019)
The focus of the work is the “phase lock-on”, a well-known phenomenon observed in oscillating dynamical systems where the forcing and output frequencies are synchronized. This phenomenon appears to be universal with the ...
Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)
(2018)
Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for maximal efficacy remains adversely low. By and ...