Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering: Recent submissions
Now showing items 141-160 of 1036
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Book Chapter
Encroachment of Traditional Electrospinning
(Royal Society of Chemistry, 2018)The recognition of electrospinning as one of the most promising top-down approaches in the fabrication of one-dimensional (1D) nanofibrous materials exhibiting high potential for use in many industrial applications has ...
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Book Chapter
Thermoresponsive Electrospun Polymer-based (Nano)fibers
(John Wiley & Sons, Ltd, 2018)This chapter presents a brief overview of the electrospinning process followed by a literature survey on the fabrication of poly(N-isopropylacrylamide)(PNIPAM)-based electrospun (nano)fibers and their applications. It ...
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Conference Object
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Article
Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
(2019)The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the ...
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Article
Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery
(2019)Inhalation therapy is a hallmark of modern respiratory medicine. Over recent years, computational fluid-particle dynamics (CFPD) simulations of respiratory airflows and aerosol deposition in the lungs have rapidly developed ...
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Article
Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations
(2019)Non-spherical particles, and fibers in particular, are potentially attractive airborne carriers for pulmonary drug delivery. Not only do they exhibit a high surface-to-volume ratio relative to spherical aerosols, but their ...
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Article
Phase lock-on in periodically excited Bingham flow past a confined cylinder
(2019)The focus of the work is the “phase lock-on”, a well-known phenomenon observed in oscillating dynamical systems where the forcing and output frequencies are synchronized. This phenomenon appears to be universal with the ...
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Article
Regional aerosol deposition in the human airways: The SimInhale benchmark case and a critical assessment of in silico methods
(2018)Regional deposition effects are important in the pulmonary delivery of drugs intended for the topical treatment of respiratory ailments. They also play a critical role in the systemic delivery of drugs with limited lung ...
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Article
Experimental methods for flow and aerosol measurements in human airways and their replicas
(2018)Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant ...
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Conference Object
Number size distribution of particles dosed by MDI and DPI inhalers
(2018)The purpose of this research was to determine the influence of inspiratory flow rate and relative humidity on particle size distributions (PSDs) generated by three MDI inhalers (Flutiform, Fullhale and Ventolin) and one ...
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Article
Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
(2018)It is widely acknowledged that inhaled fibers, e.g. air pollutants and anthropogenic particulate matter, hold the ability to deposit deep into the lungs reaching the distal pulmonary acinar airways as a result of their ...
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Article
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Article
An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung
(2018)High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to ...
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Article
PIV measurements of the SimInhale benchmark case
(2019)Particle Image Velocimetry (PIV) measurements with the aim of providing experimental data for the SimInhale benchmark case are presented within this work. We, therefore, present a refractive index matched, transparent model ...
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Article
In silico assessment of mouth-throat effects on regional deposition in the upper tracheobronchial airways
(2018)Regional deposition of inhaled medicines is a valuable metric of effectiveness in drug delivery applications to the lung. In silico methods are now emerging as a valuable tool for the detailed description of localized ...
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Article
Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)
(2018)Despite the prevalence of inhalation therapy in the treatment of pediatric respiratory disorders, most prominently asthma, the fraction of inhaled drugs reaching the lungs for maximal efficacy remains adversely low. By and ...
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Conference Object
Investigation of multi-scale behaviour of air quality data in an urban environment
(University of Notre Dame, IN, USA, 2018)
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Article
Optimizing the Detection Performance of Smart Camera Networks Through a Probabilistic Image-Based Model
(2018)Networks of smart cameras, equipped with on-board processing and communication infrastructure, are increasingly being deployed in a variety of different application fields, such as security and surveillance, traffic ...
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Conference Object
Particle-Laden Flow in a Physiologically Realistic Human Airway Bifurcation
(Springer International Publishing, 2018)Predicting regional deposition patterns of inhaled aerosols is important for the design and optimization of pharmaceutical formulations.
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Conference Object
The Effect of Flow Rate and Electrostatic Charge on Aerosol Deposition in a Realistic Lung Geometry
(Springer International Publishing, 2018)To be able to predict the fate of therapeutic or pollutant xenobiotic inhaled particles in the human lungs, we need to understand the nature of airflow as it occurs throughout the entire respiratory tract.