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dc.contributor.authorEscoffre, Jean-Michelen
dc.contributor.authorMannaris, Christophorosen
dc.contributor.authorNovell, Anthonyen
dc.contributor.authorRioc, Laëtitiaen
dc.contributor.authorMeyre, Marie-Edithen
dc.contributor.authorGermain, Matthieuen
dc.contributor.authorAVERKIOU, MICHALAKIS A.en
dc.contributor.authorBouakaz, Ayacheen
dc.creatorEscoffre, Jean-Michelen
dc.creatorMannaris, Christophorosen
dc.creatorNovell, Anthonyen
dc.creatorRioc, Laëtitiaen
dc.creatorMeyre, Marie-Edithen
dc.creatorGermain, Matthieuen
dc.creatorAVERKIOU, MICHALAKIS A.en
dc.creatorBouakaz, Ayacheen
dc.date.accessioned2019-05-06T12:23:33Z
dc.date.available2019-05-06T12:23:33Z
dc.date.issued2012
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48324
dc.description.abstractLocal drug delivery of doxorubicin holds promise to improve the therapeutic efficacy and to reduce toxicity profiles. Here, we investigated the release of doxorubicin from thermosensitive liposomes (Dox-TSL) into human glioblastoma (U-87MG) cells. Using Dox-TSL, experiments were carried out in a water bath and showed that 15 min incubation of TSL at 43°C induced the release of 80% doxorubicin loaded TSL compared to the release at 37°C. The cytotoxicity of a range of concentrations of Dox-TSL was also evaluated on U-87MG cells. At 37°C, no cytotoxicity was observed, whereas at 43°C the results showed that the cytotoxicity is dose dependent. At maximal dose of doxorubicin (30 µg/mL), the cell viability was less than 20%. Application of 15 min of HIFU at 1 MHz, 1.5 MPa and 50% duty cycle induced the release of 100% of doxorubicin from Dox-TSL. In the same experimental condition, the cell viability decreased to 40% and 20% at 12h and 48h, respectively, in comparison to that obtained during the incubation of cells with Dox-TSL alone without HIFU. In conclusion, a significant release of doxorubicin from temperature-sensitive liposomes can be achieved leading to an efficient treatment and cell death of tumor cells using HIFU. ABSTRACT FROM AUTHOR]en
dc.description.abstractCopyright of AIP Conference Proceedings is the property of American Institute of Physics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)en
dc.sourceAIP Conference Proceedingsen
dc.subjectDOXORUBICINen
dc.subjectDRUG delivery systemsen
dc.subjectLIPOSOMESen
dc.subjectCANCER cellsen
dc.subjectCELL-mediated cytotoxicityen
dc.subjectDRUGS – Toxicologyen
dc.subjectTEMPERATURE measurementsen
dc.titleHigh-intensity focused ultrasound-mediated doxorubicin delivery with thermosensitive liposomesen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume1481
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidAverkiou, Michalakis A. [0000-0002-2485-3433]
dc.description.totalnumpages81
dc.gnosis.orcid0000-0002-2485-3433


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