Double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization
AuthorKitiri, E. N.
Patrickios, C. S.
Google Scholar check
MetadataShow full item record
This manuscript presents the preparation and study of a new double-network hydrogel system, comprising an amphiphilic, pH-responsive first polymer conetwork synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and a second hydrophilic polymer network prepared via free radical photopolymerization. The amphiphilic character of the first conetwork led to its phase separation on the nanoscale, as indicated by small-angle neutron scattering (SANS) in deuterium oxide, whereas the presence of segments consisting of tertiary amine-bearing monomer repeating units resulted in pH-dependent equilibrium swelling in water. Finally, the introduction of a second, reinforcing network into the structure of the first conetwork produced a double-network hydrogel system with mechanical properties (compressive stress and strain at break, and low-strain elastic modulus) superior to those of the first conetwork. Thus, the present complex hydrogel system bears three important functions: high mechanical properties to endure an environment with high stresses, hydrophobic pockets to solubilize non-polar substances within an overall aqueous milieu, and an ability to respond to changes in pH. Such multi-functional water-swollen polymer systems can pave the way toward next-generation biomaterials. © 2016 The Royal Society of Chemistry.
Showing items related by title, author, creator and subject.
Synthesis and characterization of hyperbranched amphiphilic block copolymers prepared via self-condensing RAFT polymerization Rikkou-Kalourkoti, Maria D.; Elladiou, Marios; Patrickios, Costas S. (2015)Four families of hyperbranched amphiphilic block copolymers of styrene (Sty, less polar monomer) and 2-vinylpyridine (2VPy, one of the two more polar monomers) or 4-vinylpyridine (4VPy, the other polar monomer) were prepared ...
Poly(ethylene glycol)-based amphiphilic model conetworks: Synthesis by RAFT polymerization and characterization Achilleos, Mariliz; Legge, T. M.; Perrier, S.; Patrickios, Costas S. (2008)Polyethylene glycol) (PEG)-containing quasi-model amphiphilic polymer conetworks (APCNs) were prepared by reversible addition fragmentation chain transfer (RAFT) polymerization using α,ω-bis(2-cyanoprop-2-yl dithiobenzoate)-PEG ...
Styrene-vinyl pyridine diblock copolymers: Achieving high molecular weights by the combination of anionic and reversible addition-fragmentation chain transfer polymerizations Pafiti, Kyriaki S.; Patrickios, Costas S.; Filiz, Volkan; Rangou, Sofia; Abetz, Clarissa; Abetz, Volker (2013)Anionic and reversible addition-fragmentation chain transfer (RAFT) polymerizations were combined for the preparation of high molecular weight (MW) amphiphilic diblock copolymers based on the hydrophobic styrene (Sty) and ...