Show simple item record

dc.contributor.authorOstrovski, Y.en
dc.contributor.authorDorfman, S.en
dc.contributor.authorMezhericher, M.en
dc.contributor.authorKassinos, Stavros C.en
dc.contributor.authorSznitman, J.en
dc.creatorOstrovski, Y.en
dc.creatorDorfman, S.en
dc.creatorMezhericher, M.en
dc.creatorKassinos, Stavros C.en
dc.creatorSznitman, J.en
dc.date.accessioned2019-05-06T12:24:14Z
dc.date.available2019-05-06T12:24:14Z
dc.date.issued2018
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48665
dc.description.abstractThe pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the lungs, our ability to target or confine the deposition of inhalation aerosols to specific lung regions remains meagre. Here, we present a novel inhalation proof-of-concept in silico for regional targeting in the upper airways, quantitatively supported by computational fluid dynamics (CFD) simulations of inhaled micron-sized particles (i.e. 1-10 μm) using an intubated, anatomically-realistic, multi-generation airway tree model. Our targeting strategy relies on selecting the particle release time, whereby a short-pulsed bolus of aerosols is injected into the airways and the inhaled volume of clean air behind the bolus is tracked to reach a desired inhalation depth (i.e. airway generations). A breath hold maneuver then follows to facilitate deposition, via sedimentation, before exhalation resumes and remaining airborne particles are expelled. Our numerical findings showcase how particles in the range 5-10 μm combined with such inhalation methodology are best suited to deposit in the upper airways, with deposition fractions between 0.68 and unity. In contrast, smaller (< 2 μm) particles are less than optimal due to their slow sedimentation rates. We illustrate further how modulating the volume inhaled behind the pulsed bolus, prior to breath hold, may be leveraged to vary the targeted airway sites. We discuss the feasibility of the proposed inhalation framework and how it may help pave the way for specialized topical lung treatments. © 2018 Springer Science+Business Media B.V., part of Springer Natureen
dc.language.isoengen
dc.sourceFlow, Turbulence and Combustionen
dc.subjectComputational fluid dynamicsen
dc.subjectSedimentation ratesen
dc.subjectControlled drug deliveryen
dc.subjectSedimentationen
dc.subjectAerosolsen
dc.subjectAtmospheric movementsen
dc.subjectComputational fluid dynamics simulationsen
dc.subjectLungsen
dc.subjectInhalation medicineen
dc.subjectAerosol transporten
dc.subjectBiological organsen
dc.subjectCFDen
dc.subjectDeposition fractionsen
dc.subjectMedicineen
dc.subjectMicron-sized particlesen
dc.subjectTargeted drug deliveryen
dc.subjectTopical treatmentsen
dc.subjectVolume tracking methoden
dc.titleTargeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Methoden
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s10494-018-9927-1
dc.description.startingpage1
dc.description.endingpage15
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidKassinos, Stavros C. [0000-0002-3501-3851]
dc.description.totalnumpages1-15


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record