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dc.contributor.authorRadhakrishnan, H.en
dc.contributor.authorKassinos, Stavros C.en
dc.creatorRadhakrishnan, H.en
dc.creatorKassinos, Stavros C.en
dc.description.abstractUnderstanding transport and deposition of inhaled particles in the human airways plays a crucial role in the targeted therapy of pulmonary diseases, and the administration of inhaled medicines. Numerous researchers have studied the inhalation of particles using experiments or computer models. Even though experiments have shown that the airflow in the trachea and the upper branches of the lung is turbulent, the flow is taken to be laminar in most computer models. Only few recently published papers have looked at the turbulent transport of air in the human airways. Even fewer results have been published on the effect of the upper airway structures on the turbulent airflow in the lungs or on the effect of the turbulence on particle deposition. The previously published turbulent models have also mainly used RANS methods to predict the flow. To study the unsteady flow and particle deposition in a human lung, an LES model with a dynamic Smagorinsky subgrid scale model was used. The model equations were solved to study steady inspirational flow at different flow rates for different particle sizes. Results indicate that the upper airway geometry produces turbulence in the flow and the deposition of particles is mainly affected by the particle size and Stokes number. ©2009 IEEE.en
dc.publisherAffiliation: UCY-CompSci Computational Sciences Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprusen
dc.publisherCorrespondence Address: Radhakrishnan, H.en
dc.publisherUCY-CompSci Computational Sciences Laboratory, Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprusen
dc.sourceProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009en
dc.subjectComputational fluid dynamicsen
dc.subjectModel equationsen
dc.subjectStokes numberen
dc.subjectUpper airwayen
dc.subjectParticle depositionsen
dc.subjectBiological organsen
dc.subjectComputer modelsen
dc.subjectHuman airwayen
dc.subjectHuman lungen
dc.subjectInhaled particlesen
dc.subjectRespiratory mechanicsen
dc.subjectTurbulent modelsen
dc.subjectTurbulent transportsen
dc.subjectCFD modelingen
dc.subjectSmagorinsky subgrid scale modelen
dc.titleCFD modeling of turbulent flow and particle deposition in human lungsen
dc.description.endingpage2870Πολυτεχνική Σχολή / Faculty of EngineeringΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeConference Objecten
dc.contributor.orcidKassinos, Stavros C. [0000-0002-3501-3851]

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