AM-FM texture image analysis in brain white matter lesions in the progression of multiple sclerosis
AuthorLoizou, Christos P.
Pattichis, Marios S.
Pantzaris, Marios C.
Pattichis, Constantinos S.
SourceProceedings of the IEEE Southwest Symposium on Image Analysis and Interpretation
2010 IEEE Southwest Symposium on Image Analysis and Interpretation, SSIAI 2010
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We present the use of multiscale Amplitude Modulation Frequency Modulation (AM-FM) methods for analyzing brain white matter lesions that are associated with disease progression. We analyze lesions and normal appearing white matter (NAWM) longitudinally (0 and 6 months) and also for progression of disease. We use the expanded disability status scale (EDSS) to assess disease progression. The findings suggest that the high-frequency scale instantaneous amplitude can be used to differentiate between lesions associated with early and advanced disease stages. The classification results using the IF information and support vector machines produced a maximum sensitivity of 0.86, specificity of 0.76 and a maximum correct classification of 0.71. © 2010 IEEE.