dc.contributor.author | Tamaddoni-Nezhad, A. | en |
dc.contributor.author | Chaleil, R. | en |
dc.contributor.author | Kakas, Antonis C. | en |
dc.contributor.author | Muggleton, S. | en |
dc.creator | Tamaddoni-Nezhad, A. | en |
dc.creator | Chaleil, R. | en |
dc.creator | Kakas, Antonis C. | en |
dc.creator | Muggleton, S. | en |
dc.date.accessioned | 2019-11-13T10:42:26Z | |
dc.date.available | 2019-11-13T10:42:26Z | |
dc.date.issued | 2005 | |
dc.identifier.isbn | 0-7695-2495-8 | |
dc.identifier.isbn | 978-0-7695-2495-5 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55050 | |
dc.description.abstract | This paper describes the use of a mixture of abduction and induction for the temporal modelling of the effects of toxins in metabolic networks. Background knowledge is used which describes network topology and functional classes of enzymes. This background knowledge, which represents the present state of understanding, is incomplete. In order to overcome this incompleteness hypotheses are considered which consist of a mixture of specific inhibitions of enzymes (ground facts) together with general (non-ground) rules which predict classes of enzymes likely to be inhibited by the toxin. The foreground examples were derived from in vivo experiments involving NMR analysis of time-varying metabolite concentrations in rat urine following injections of toxin. Hypotheses about inhibition are built using the Inductive Logic Programming system Progo15.0 and predictive accuracy is assessed for both the ground and the non-ground cases. © 2005 IEEE. | en |
dc.source | Proceedings - ICMLA 2005: Fourth International Conference on Machine Learning and Applications | en |
dc.source | ICMLA 2005: 4th International Conference on Machine Learning and Applications | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847276702&doi=10.1109%2fICMLA.2005.6&partnerID=40&md5=c5b8b8a8d96d9763885ebe4b620cd452 | |
dc.subject | Mathematical models | en |
dc.subject | Network topologies | en |
dc.subject | Medical computing | en |
dc.subject | Enzymes | en |
dc.subject | Metabolism | en |
dc.subject | Biomedical engineering | en |
dc.subject | Learning systems | en |
dc.subject | Knowledge engineering | en |
dc.subject | Inductive Logic Programming | en |
dc.subject | Learning models | en |
dc.subject | Metabolic networks | en |
dc.subject | Toxic materials | en |
dc.title | Abduction and induction for learning models of inhibition in metabolic networks | en |
dc.type | info:eu-repo/semantics/conferenceObject | |
dc.identifier.doi | 10.1109/ICMLA.2005.6 | |
dc.description.volume | 2005 | |
dc.description.startingpage | 233 | |
dc.description.endingpage | 238 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Πληροφορικής / Department of Computer Science | |
dc.type.uhtype | Conference Object | en |
dc.description.notes | <p>Sponsors: California State University | en |
dc.description.notes | Bakersfield and Association for Machine Learning and Applications | en |
dc.description.notes | Conference code: 69275 | en |
dc.description.notes | Cited By :3</p> | en |
dc.contributor.orcid | Kakas, Antonis C. [0000-0001-6773-3944] | |
dc.gnosis.orcid | 0000-0001-6773-3944 | |