dc.contributor.author | Child, E. S. | en |
dc.contributor.author | Georgiades, Savvas N. | en |
dc.contributor.author | Rose, K. N. | en |
dc.contributor.author | Stafford, V. S. | en |
dc.contributor.author | Patel, C. B. K. | en |
dc.contributor.author | Steinke, J. H. G. | en |
dc.contributor.author | Mann, D. J. | en |
dc.contributor.author | Vilar, R. | en |
dc.creator | Child, E. S. | en |
dc.creator | Georgiades, Savvas N. | en |
dc.creator | Rose, K. N. | en |
dc.creator | Stafford, V. S. | en |
dc.creator | Patel, C. B. K. | en |
dc.creator | Steinke, J. H. G. | en |
dc.creator | Mann, D. J. | en |
dc.creator | Vilar, R. | en |
dc.date.accessioned | 2019-11-21T06:17:19Z | |
dc.date.available | 2019-11-21T06:17:19Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1864-6158 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55322 | |
dc.description.abstract | Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent - albeit not always selective - kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metalbased compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. © Springer-Verlag 2011. | en |
dc.source | Journal of Chemical Biology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-81955161269&doi=10.1007%2fs12154-011-0059-5&partnerID=40&md5=6626788b9a3a7b9960f12bc132bd1832 | |
dc.subject | article | en |
dc.subject | priority journal | en |
dc.subject | dose response | en |
dc.subject | platinum complex | en |
dc.subject | gefitinib | en |
dc.subject | polyacrylamide gel electrophoresis | en |
dc.subject | mitogen activated protein kinase | en |
dc.subject | Platinum | en |
dc.subject | MAPK | en |
dc.subject | enzyme inhibition | en |
dc.subject | chemical structure | en |
dc.subject | complex formation | en |
dc.subject | proton nuclear magnetic resonance | en |
dc.subject | enzyme assay | en |
dc.subject | electrospray mass spectrometry | en |
dc.subject | cyclin dependent kinase 2 | en |
dc.subject | Bioinorganic | en |
dc.subject | carbon nuclear magnetic resonance | en |
dc.subject | Cdk | en |
dc.subject | cyclin dependent kinase 2 inhibitor | en |
dc.subject | enzyme purification | en |
dc.subject | ERK | en |
dc.subject | indirubin | en |
dc.subject | Inhibitor | en |
dc.subject | Kinase | en |
dc.subject | mitogen activated protein kinase 1 | en |
dc.subject | mitogen activated protein kinase inhibitor | en |
dc.subject | phenanthroline derivative | en |
dc.subject | roscovitine | en |
dc.subject | staurosporine | en |
dc.title | Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1007/s12154-011-0059-5 | |
dc.description.volume | 4 | |
dc.description.issue | 4 | |
dc.description.startingpage | 159 | |
dc.description.endingpage | 165 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Tradenames: iressa | en |
dc.description.notes | Cited By :1</p> | en |
dc.source.abbreviation | J.Chem.Biol. | en |
dc.contributor.orcid | Georgiades, Savvas N. [0000-0002-6106-9904] | |
dc.gnosis.orcid | 0000-0002-6106-9904 | |