dc.contributor.author | Christoforou, Irene C. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.contributor.author | Rees, C. W. | en |
dc.creator | Christoforou, Irene C. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.creator | Rees, C. W. | en |
dc.date.accessioned | 2019-11-21T06:17:21Z | |
dc.date.available | 2019-11-21T06:17:21Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1477-0520 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55328 | |
dc.description.abstract | 3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with respect to base, phase transfer agent and palladium catalyst. Suzuki coupling at C-5 was also achieved in high yield using potassium phenyltrifluoroborate. The regiospecificity of either coupling method is maintained with 3,5-dibromoisothiazole-4-carbonitrile 4 to give exclusively 3-bromo-5-phenylisothiazole-4-carbonitrile 5. Suzuki cross-coupling conditions applied to 3-chloro-5-phenylisothiazole-4-carbonitrile 2a gave 3-phenoxy-5-phenylisothiazole-4-carbonitrile 6, which was prepared independently, and not the 3-phenyl derivative. All isothiazole products were fully characterized. | en |
dc.source | Organic and Biomolecular Chemistry | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041818289&doi=10.1039%2fb306005e&partnerID=40&md5=3f927be12b56f106c547c4a6c347a4f4 | |
dc.subject | Optimization | en |
dc.subject | Reaction kinetics | en |
dc.subject | Crystal structure | en |
dc.subject | Phase transitions | en |
dc.subject | Palladium | en |
dc.subject | Catalysts | en |
dc.subject | Organic compounds | en |
dc.subject | Dichloroisothiazole carbonitrile | en |
dc.subject | Lateolabrax japonicus | en |
dc.subject | Organoboronic acids | en |
dc.subject | Regiospecific Suzuki coupling | en |
dc.title | Regiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrile | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1039/b306005e | |
dc.description.volume | 1 | |
dc.description.issue | 16 | |
dc.description.startingpage | 2900 | |
dc.description.endingpage | 2907 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :34</p> | en |
dc.source.abbreviation | Org.Biomol.Chem. | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.contributor.orcid | Christoforou, Irene C. [0000-0001-6624-3548] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |
dc.gnosis.orcid | 0000-0001-6624-3548 | |