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dc.contributor.authorChristoforou, Irene C.en
dc.contributor.authorKoutentis, Panayiotis Andreasen
dc.contributor.authorRees, C. W.en
dc.creatorChristoforou, Irene C.en
dc.creatorKoutentis, Panayiotis Andreasen
dc.creatorRees, C. W.en
dc.date.accessioned2019-11-21T06:17:21Z
dc.date.available2019-11-21T06:17:21Z
dc.date.issued2003
dc.identifier.issn1477-0520
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55328
dc.description.abstract3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with respect to base, phase transfer agent and palladium catalyst. Suzuki coupling at C-5 was also achieved in high yield using potassium phenyltrifluoroborate. The regiospecificity of either coupling method is maintained with 3,5-dibromoisothiazole-4-carbonitrile 4 to give exclusively 3-bromo-5-phenylisothiazole-4-carbonitrile 5. Suzuki cross-coupling conditions applied to 3-chloro-5-phenylisothiazole-4-carbonitrile 2a gave 3-phenoxy-5-phenylisothiazole-4-carbonitrile 6, which was prepared independently, and not the 3-phenyl derivative. All isothiazole products were fully characterized.en
dc.sourceOrganic and Biomolecular Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0041818289&doi=10.1039%2fb306005e&partnerID=40&md5=3f927be12b56f106c547c4a6c347a4f4
dc.subjectOptimizationen
dc.subjectReaction kineticsen
dc.subjectCrystal structureen
dc.subjectPhase transitionsen
dc.subjectPalladiumen
dc.subjectCatalystsen
dc.subjectOrganic compoundsen
dc.subjectDichloroisothiazole carbonitrileen
dc.subjectLateolabrax japonicusen
dc.subjectOrganoboronic acidsen
dc.subjectRegiospecific Suzuki couplingen
dc.titleRegiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrileen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1039/b306005e
dc.description.volume1
dc.description.issue16
dc.description.startingpage2900
dc.description.endingpage2907
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :34</p>en
dc.source.abbreviationOrg.Biomol.Chem.en
dc.contributor.orcidKoutentis, Panayiotis Andreas [0000-0002-4652-7567]
dc.contributor.orcidChristoforou, Irene C. [0000-0001-6624-3548]
dc.gnosis.orcid0000-0002-4652-7567
dc.gnosis.orcid0000-0001-6624-3548


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