Organic vanadium compounds - Transition state analogy with organic phosphorus compounds
Date
1996ISSN
1042-6507Source
Phosphorus, Sulfur and Silicon and Related ElementsVolume
109Issue
1-4Pages
245-248Google Scholar check
Metadata
Show full item recordAbstract
Vanadium compounds, particularly in oxidation state V, are potent inhibitors of phosphoryl group transfer enzymes. In this paper the existance of a correlation between the coordination geometry of a series of vanadium dipicolinate complexes and their potency as inhibitors for chicken intestinal alkaline phosphatase is examined. We find that within a limited series of vanadium compounds the five-coordinate derivatives are the most potent inhibitors.