Organic vanadium compounds - Transition state analogy with organic phosphorus compounds
AuthorCrans, D. C.
Keramidas, Anastasios D.
SourcePhosphorus, Sulfur and Silicon and Related Elements
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Vanadium compounds, particularly in oxidation state V, are potent inhibitors of phosphoryl group transfer enzymes. In this paper the existance of a correlation between the coordination geometry of a series of vanadium dipicolinate complexes and their potency as inhibitors for chicken intestinal alkaline phosphatase is examined. We find that within a limited series of vanadium compounds the five-coordinate derivatives are the most potent inhibitors.